首页> 外文期刊>Journal of Korean medical science >Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin.
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Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin.

机译:皮肤衰老和光学或脂肪酸组合物,包括11,14,17-己二烯酸,在人体皮肤的表皮中。

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摘要

We investigated the alterations of major fatty acid components in epidermis by natural aging and photoaging processes, and by acute ultraviolet (UV) irradiation in human skin. Interestingly, we found that 11,14,17-eicosatrienoic acid (ETA), which is one of the omega-3 polyunsaturated acids, was significantly increased in photoaged human epidermis in vivo and also in the acutely UV-irradiated human skin in vivo, while it was significantly decreased in intrinsically aged human epidermis. The increased ETA content in the epidermis of photoaged human skin and acute UV-irradiated human skin is associated with enhanced expression of human elongase 1 and calcium-independent phosphodiesterase A(2). We demonstrated that ETA inhibited matrix metalloproteinase (MMP)-1 expression after UV-irradiation, and that inhibition of ETA synthesis using EPTC and NA-TCA, which are elongase inhibitors, increased MMP-1 expression. Therefore, our results suggest that the UV increases the ETA levels, which may have a photoprotective effect in the human skin.
机译:我们调查了通过天然老化和光学手册过程的表皮中主要脂肪酸组分的改变,以及人体皮肤中的急性紫外(UV)辐射。有趣的是,我们发现11,14,17- eicosatrienoider(ETA),其是ω-3多不饱和酸的一种,在体内的相似性人体表皮中显着增加,并且在体内急性紫外线辐照的人体皮肤中,虽然本质上老年人的人表皮中显着降低。相应的人体皮肤和急性紫外线照射的人体皮肤表皮中的ETA含量增加与人类延长酶1的增强表达和无关的磷酸钙酶A(2)相关。我们证明,紫外线辐射后ETA抑制基质金属蛋白酶(MMP)-1表达,并且使用ePTC和NA-TCA的ETA合成抑制,所述EPTC和NA-TCA是延长酶抑制剂,增加MMP-1表达。因此,我们的结果表明UV增加了ETA水平,这可能在人体皮肤中具有光保护作用。

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