Synthesis of tritiated Cyclosporin A and FK-506 by metal-catalyzed hydrogen isotope exchange

V. P. Shevchenko; I. Yu. Nagaev; N. F. Myasoedov; H. Andres; T. Moenius; A. Susan

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Synthesis of tritiated Cyclosporin A and FK-506 by metal-catalyzed hydrogen isotope exchange

机译：金属催化氢同位素交换合成氚孢菌素A和FK-506的合成

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Tritium-labeled Cyclosporin A (I) and FK-506 (II) have been prepared using a metal-catalysed hydrogen isotope exchange procedure and high specific activity tritiated water. Specific activities of the labeled compounds were 0.15 and 0.59TBq/mmol, respectively.

机译：使用金属催化的氢同位素交换程序和高特异性活性氚化水制备了氚标记的环孢菌素A（I）和FK-506（II）。标记化合物的比活性分别为0.15和0.59TBQ / mmol。

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来源
《Journal of Labelled Compounds and Radiopharmaceuticals》 |2004年第7期|共8页
作者
V. P. Shevchenko; I. Yu. Nagaev; N. F. Myasoedov; H. Andres; T. Moenius; A. Susan;
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作者单位

Institute of Molecular Genetics Russian Academy of Sciences pi. Akademika Kurchatova 2 Moscow 123182 Russia;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
tritium; labeling; H/T-exchange; FK506; cyclosporin A;

机译：氚;标记;H / T交换;FK506;环孢菌素A;
入库时间 2022-08-20 09:30:08

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1. Synthesis of tritiated Cyclosporin A and FK-506 by metal-catalyzed hydrogen isotope exchange [J] . V. P. Shevchenko, I. Yu. Nagaev, N. F. Myasoedov, Journal of Labelled Compounds and Radiopharmaceuticals . 2004,第7期

机译：金属催化氢同位素交换合成氚孢菌素A和FK-506的合成
2. Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange [J] . Palazzolo Alberto, Feuillastre Sophie, Pfeifer Viktor, Angewandte Chemie . 2019,第15期

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Synthesis of tritiated Cyclosporin A and FK-506 by metal-catalyzed hydrogen isotope exchange

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