Reduction of [ 11 11 C]CO 2 2 to [ 11 11 C]CO using solid supported zinc

摘要

A new method for the reduction of no‐carrier‐added [ 11 C]carbon dioxide into [ 11 C]carbon monoxide ([ 11 C]CO) is described, in which the reductant (zinc) is supported on fused silica particles. Using this setup, which allows for a reduction temperature (485°C) well above the melting point for zinc (420°C), radiochemical yields of up to 96% (decay‐corrected) were obtained. A slight decrease in radiochemical yield was observed upon repeated [ 11 C]CO productions (93?±?3%, n ?=?20). The methodology is convenient and efficient and provides a straightforward path to no‐carrier‐added production of [ 11 C]CO.