Synthesis of radio- and stable-labeled LBH589 (Panabinostat) to support animal and human ADME studies

摘要

Radiolabeled LBH589 was required to support animal and human ADME studies and also in vitro protein binding study. Stable labeled LBH589 (with an appropriately high number of labeled mass units) was also needed as an LC/MS internal standard for use in bioanalytical assays.