The synthesis of tritium-labeled compounds

摘要

Tritium-labeled compounds are synthesized frequently in our group in order to assess metabolism. Tritium is the label of choice because these compounds can be synthesized rapidly in most circumstances. Tritium gas and tritiated water are common label sources, in addition to other commercially available tritiating reagents. This paper will focus on recent uses of sodium borotritide, [~3H]methyl nosylate, and iridium catalysts with tritium gas or tritiated water in our lab.