The synthesis of 5,7-dimethyl-1,2,4-triazolo(1,5a(~(14)C)) pyrimidine-2-carbaldehyde from (~(14)C)aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate

Rane; Klaas; A.M.; S.

首页> 外文期刊>Journal of Labelled Compounds and Radiopharmaceuticals >The synthesis of 5,7-dimethyl-1,2,4-triazolo(1,5a(~(14)C)) pyrimidine-2-carbaldehyde from (~(14)C)aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate

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The synthesis of 5,7-dimethyl-1,2,4-triazolo(1,5a(~(14)C)) pyrimidine-2-carbaldehyde from (~(14)C)aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate

机译：合成5,7-二甲基-1,2,4-三唑（1,5a（〜（14）c））嘧啶-2-甲醛（〜（14）c）氨基胍：放射性化学GMP的关键中间体毒品候选人的合成

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Hydrazination of barium [~(14)C]cyanamide and hydrazinolysis of S-methylisothio[~(14)C]urea were compared for their ability to efficiently prepare [~(14)C]aminoguanidine bicarbonate. [ ~(14)C]Aminoguanidine bicarbonate was converted in three steps to 5, 7-dimethyl-1,2,4-triazolo[1,5a(~(14)C)]pyrimidine-2-carbaldehyde, a key radiochemical GMP starting material.

机译：比较钡的氢化钡[〜（14）c]氰酰胺和S-甲基噻嗪的肼分解[〜（14）C]尿素，以有效制备[〜（14）C]氨基胍碳酸氢盐的能力。 [〜（14）C]氨基胍碳酸氢盐以三个步骤转化为5,7-二甲基-1,2,4-三唑唑[1,5A（〜（14）C）]嘧啶-2-甲醛，是一种关键的放射性化学GMP 起始材料。

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来源
《Journal of Labelled Compounds and Radiopharmaceuticals》 |2010年第6期|共4页
作者
Rane; Klaas; A.M.; S.;
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作者单位

Pfizer Global Research and Development Eastern Point Road Groton CT 06340 United States;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
5; 7-dimethyl-1; 2; 4-triazolo1; 5a( ~(14)C)pyrimidine-2-carbaldehyde; ~(14)Caminoguanidine bicarbonate; Barium ~(14)Ccyanamide; S-methylisothio~(14)Curea;

机译：5;7-二甲基-1;2;4-三唑罗[1;5A（〜（14）c）]嘧啶-2-碳醛;[〜（14）c]氨基胍碳酸氢盐;钡[〜（14）C]氰酰胺;S-甲基噻噻肟[〜（14）c]尿素;

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1. The synthesis of 5,7-dimethyl-1,2,4-triazolo(1,5a(~(14)C)) pyrimidine-2-carbaldehyde from (~(14)C)aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate [J] . Rane, Klaas, A.M., Journal of Labelled Compounds and Radiopharmaceuticals . 2010,第5a6期

机译：由（〜（14）C）氨基胍合成5,7-二甲基-1,2,4-三唑并（1,5a（〜（14）C））嘧啶-2-甲醛：放射化学GMP的关键中间体候选药物的合成
2. The synthesis of 5,7-dimethyl-1,2,4-triazolo(1,5a(~(14)C)) pyrimidine-2-carbaldehyde from (~(14)C)aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate [J] . Rane, Klaas, A.M., Journal of Labelled Compounds and Radiopharmaceuticals . 2010,第5a6期

机译：合成5,7-二甲基-1,2,4-三唑（1,5a（〜（14）c））嘧啶-2-甲醛（〜（14）c）氨基胍：放射性化学GMP的关键中间体毒品候选人的合成
3. The synthesis of 5,7-dimethyl-1,2,4-triazolo(1,5a(~(14)C)) pyrimidine-2-carbaldehyde from (~(14)C)aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate [J] . Rane, Klaas, A.M., Journal of Labelled Compounds and Radiopharmaceuticals . 2010,第5a6期

机译：合成5,7-二甲基-1,2,4-三唑（1,5a（〜（14）c））嘧啶-2-甲醛（〜（14）c）氨基胍：放射性化学GMP的关键中间体毒品候选人的合成
4. Synthesis of 5-Methyl-1,2,4-triazolo1,5- aPyrimidin-7(4H)-one - a Semi-Product of the Synthesis of Antiviral Drug Triazide? in the Conditions of Microwave Excitation [C] . Artem V. Baklykov, Gennady L. Rusinov, Grigory A. Artemev, International Conference on Modern Synthetic Methodologies for Creating Drugs and Functional Materials . 2019

机译：合成5-甲基-1,2,4-三唑的1,5- A嘧啶-7（4H） - 酮 - 抗病毒药物三叠氮氧化物合成的半产物吗？在微波励磁条件下
5. Data for the synthesis and characterisation of 26-di(bromomethyl)-35-bis(alkoxycarbonyl)-4-aryl-14-dihydropyridines as important intermediates for synthesis of amphiphilic 14-dihydropyridines [O] . Martins Rucins, Klavs Pajuste, Arkadij Sobolev, 2020

机译：26-二（溴甲基）-35-双（烷氧基羰基）-4-芳基-14-二氢吡啶的合成和表征数据是合成两亲性14-二氢吡啶的重要中间体
6. Synthesis, spectroscopic characterization and in vitro antimicrobial activity of diorganotin(IV) dichloride adducts with 1,2,4triazolo-1,5-apyrimidine and 5,7-dimethyl-1,2,4triazolo-1,5,apyrimidine. [O] . GIRASOLO MA, SCHILLACI D, DI SALVO C, 2006

机译：二有机锡（IV）与1,2,4三唑-1,5-a嘧啶和5,7-二甲基-1,2,4三唑-的二氯化二有机锡（IV）加合物的合成，光谱表征和体外抗菌活性1,5，a嘧啶。
7. Synthesis of 14C-Labelled Octahydor-1,3, 5,7-Tetranitro-1,3,5,7- Tetrazocine HMx0 and 15N-Isotopic Hexahyrro-1,3,5- Trinitro-1,3,5-Triazine (RDX) for use in Microcosm Experiments [R] . Ampleman, G. , Marois, A. , Thiboutot, S. , 2000

机译：14C-标记的Octahydor-1,3,5,7-四硝基-1,3,5,7-四氮杂辛Hmx0和15N-同位素六氢-1,3,5-三硝基-1,3,5-三嗪（RDX）的合成）用于微观世界实验

The synthesis of 5,7-dimethyl-1,2,4-triazolo(1,5a(~(14)C)) pyrimidine-2-carbaldehyde from (~(14)C)aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate

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