An Easy Synthetic Approach to Construct Some Ebselen Analogues and Benzo[ bb ]selenophene Derivatives: Their Antioxidant and Cytotoxic Assessment

摘要

> 2‐(Chloroseleno)benzoyl chloride serves as a versatile building block for the synthesis of novel ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3(2 H )‐one) analogues and benzo[ b ]selenophen‐3(2 H )‐one derivatives. The antioxidant activity and cytotoxic evaluation of the newly synthesized compounds were implemented. Among all the synthesized compounds, 1‐(3‐hydroxybenzo[ b ]selenophen‐2‐yl)ethanone oxime ( 9 ) was the most potent antioxidant and the most cytotoxic compound as well.