Synthesis of Some Novel Class of Regioselective Spiro Isoxazolidine Derivatives viavia 1,3‐Dipolar Cycloaddition Reaction of N‐N‐ Benzyl‐ C‐C‐ fluoro‐substituted Phenyl Nitrones in Ionic Liquid

摘要

> Synthesis of some new class of regioselective spiro isoxazolidine derivatives have been described using N‐ benzyl‐ C‐ fluoro substituted‐phenyl nitrones with new dipolarophiles via 1,3‐dipolar cycloaddition reaction in ionic liquid. The novel spiro cycloadducts found to exhibit good synthetic potentiality as they could be converted into synthetically more important spiro 1,3‐amino alcohols. Simple reaction methodology, noninvolvent of catalysts, good to excellent yields, and greener approaches are the important features noticed in this syntheses.