An Efficient Synthesis of Pyrrolo[1,2‐ aa ] or Pyrido[1,2‐ aa ]benzo[4,5]imidazo[1,2‐ cc ]quinazoline Derivatives in Ionic Liquids Catalyzed by Iodine

摘要

> 2‐(1 H ‐benzo[ d ]imidazol‐2‐yl)anilines reacted with haloketones including 5‐chloropentan‐2‐one and 6‐chlorohexan‐2‐one catalyzed by iodine, giving benzo[4,5]imidazo[1,2‐ c ]pyrrolo[1,2‐ a ]quinazoline and 6 H ‐benzo[4,5]imidazo[1,2‐ c ]pyrido[1,2‐ a ]quinazoline derivatives, respectively. This domino‐type reaction formed two new heterocycles and three new covalent bonds in one‐pot procedure and provided a green method for the synthesis of fused pentacyclic heterocycles bearing both quinazoline and benzimidazole moieties in ionic liquids.