DABCOmediated one pot synthesis of 2-(3-benzyl-2, 6-dioxo-3, 6-dihydropyrimidin-1[2H]-yl)-N-(4-(1,3-dioxo-1H-benzo [de]isoquinolin-2[3H]-yl) aryl) acetamides as antimicrobial agents

摘要

We report herein DABCO mediated one pot synthesis of2-(3-benzyl-2,6-dioxo-3,6-dihydropyrimidin-1[2H]-yl)-N-(4-(1,3-dioxo-1H-benzo[de]isoquinolin-2[3H]-yl) aryl) acetamides (4a-j). The silent features of this new one pot synthesis include the shorter reaction time, high yields, simple workup, and simultaneous formation ofN-Amide andN-benzyl bonds in the one pot. The newly synthesized compounds (4a-j) were characterized by different spectral techniques such as IR,H-1-NMR,C-13-NMR, HRMS. All the synthesized compounds were evaluated for their anti-bacterial and anti-fungal activities. The anti-bacterial activities results reveal that the compounds4a,4g,4i, and4jare most active againstS. aureus. In the case ofB. subtilisthe compounds4a,4i, and4jare found to be most active. The compounds4c,4e,4i, and4jare most active againstE. coli. In the case ofP. aeruginosa4a,4i & 4jare found to be more active. On the other hand, the anti-fungal activity result shows that the compounds4d,4f,4i, and4jare more active againstA. niger. The compounds4a,4d,4i, and4jare found to be more active againstC. albicans.