MgO NPs Catalyzed Eco-friendly Reaction: A Highly Effective and Green Approach for the Multicomponent One-pot Synthesis of Polysubstituted Pyridines using 2-Aminobenzothiazole

摘要

A one-pot multicomponent green and environmentally friendly synthesis of 5-amino-3-benzothiazol-2-yl-7-(phenyl)-2-phenyl-2,3-dihydro-thiazolo[4,5-b]pyridine-6-carbonitrile via Knoevenagel condensation followed by Michael addition has been described in the presence of a green, low-cost, mild, and efficient magnesium oxide as the heterogeneous base catalyst. The present methodology has attractive features such as excellent product yields, environmentally benign milder reaction conditions, use of nontoxic organic solvents, and easily recoverable and reusable nanocatalyst. The synthesized compounds have been confirmed by spectral analysis (Fourier transform infrared, H-1-NMR, C-13-NMR, and mass spectrometry).