首页> 外文期刊>Journal of hypertension >Wild-type p53-induced phosphatase 1 promotes vascular smooth muscle cell proliferation and neointima hyperplasia after vascular injury via p-adenosine 50 '-monophosphate-activatedprotein kinase/mammalian target of rapamycin complex 1 pathway
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Wild-type p53-induced phosphatase 1 promotes vascular smooth muscle cell proliferation and neointima hyperplasia after vascular injury via p-adenosine 50 '-monophosphate-activatedprotein kinase/mammalian target of rapamycin complex 1 pathway

机译:野生型P53诱导的磷酸酶1通过P-腺苷50'-单磷酸磷酸酯 - 活化蛋白激酶/哺乳动物靶标在雷帕霉素复合物1途径后促进血管平滑肌细胞增殖和新内膜增生

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摘要

Objectives: Vascular smooth muscle cell (VSMC) proliferation is a crucial cause of vascular neointima hyperplasia and restenosis, thus limiting the long-term efficacy of percutaneous vascular intervention. We explored the role of wild-type p53-induced phosphatase 1 (Wip1), a potent regulator of tumorigenesis and atherosclerosis, in VSMC proliferation and neointima hyperplasia.
机译:目的:血管平滑肌细胞(VSMC)增殖是血管内部增生和再狭窄的关键原因,从而限制了经皮血管干预的长期疗效。 我们探讨了野生型P53诱导的磷酸酶1(WIP1),肿瘤引发和动脉粥样硬化的有效调节剂的作用,在VSMC增殖和内部增殖中。

著录项

  • 来源
    《Journal of hypertension》 |2019年第11期|共13页
  • 作者单位

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

    Chengdu Mil Gen Hosp Western Theater Command Gen Hosp Dept Cardiol Chengdu Sichuan Peoples R;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 心脏、血管(循环系)疾病;
  • 关键词

    AMPK; mTORC1; vascular restenosis; VSMC proliferation; Wip1;

    机译:AMPK;MTORC1;血管再狭窄;VSMC增殖;WIP1;

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