Biomarkers for the diagnosis of thyroid cancer

摘要

Thyroid gland is the major endocrine gland which secrets thyroid hormone. Though thyroid cancer contributes 1 % of total cancer cases, but it accounts 90% of total endocrinal tumor and 60% of all death due to endocrine cancer death (1-3). The annual incidence of thyroid cancer ranges from 0.5 to 13.6 per thousand cases, and an increase in incidence from 3.2 per 100000 population in 1973 to 8.7 per 100000 population in 2002 was observed (4). This increased incidence in thyroid cancer needs attention for cancer diagnosis and its treatment. Most of the thyroid tumor is expressed as thyroid nodules, and among them 90% are benign, raises the difficulty in cancer diagnosis (5).