Genotyping a new, national household panel study: White paper prepared for NSF-sponsored Conference, May 2014

摘要

In this paper, I demonstrate that existing social surveys that include genotypic markers are all limited on at least one of the following dimensions: national representativeness (versus targeted sample), genotyping platform (candidate genes v. genome-wide measures), data structure (i.e. individuals v. pedigrees), or measured phenotypes (lack of rich longitudinal socioeconomic and developmental measures). Given this, I argue that the U.S. either needs a novel, nationally representative household panel study that includes genome-wide marker data or to genotype all respondents of the existing Panel Study of Income Dynamics. I conclude by showing that such a study would be adequately powered to deploy Genetic Risk Score analysis and that, in turn, such scores could be deployed to model gene-environment interaction effects.