Fabrication of rapid-biodegradable nano-vectors for endosomal-triggered drug delivery

摘要

Nanoparticles that respond to specific stimulus to achieve controlled release of anticancer drug have been vastly investigated for years. In this study, we focused on the development of low-residue organosilica nanoparticles (OSNPs), which were obtained by introducing biodegradable group into the monomer. DOX was loaded via the hydrophobic interaction between benzene and the drug. The drug release results revealed that the DOX could be fast liberated from the nanoparticles under acidic condition, indicating the high pH-response of the nanoparticles and the fine protection of anticancer drug. And the results of the cell viability showed promising efficiency in cancer therapy. Importantly, supported with the TEM figures and the degradation assessment, the nanoparticles were proved to be disintegrated into low molecular weight residues, rapidly and completely, predicting the possible few remains in vivo.