Higher Trough Vedolizumab Concentrations During Maintenance Therapy are Associated With Corticosteroid-Free Remission in Inflammatory Bowel Disease

Ungaro Ryan C.; Yarur Andres; Jossen Jacqueline; Phan Becky L.; Chefitz Ezra; Sehgal Priya; Kamal Kanika; Bruss Alexandra; Beniwal-Patel Poonam; Fox Caroline; Patel Amir; Bahur Bayda; Jain Anjali; Stein Daniel; Naik Snehal; Dubinsky Marla C.

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Higher Trough Vedolizumab Concentrations During Maintenance Therapy are Associated With Corticosteroid-Free Remission in Inflammatory Bowel Disease

机译：维持治疗期间的高谷Vedolizumab浓度与炎性肠病的皮质类固醇缓解有关

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Background and Aims Vedolizumab is an anti-alpha 4 beta 7 biologic approved for ulcerative colitis [UC] and Crohn's disease [CD]. We aimed to examine the association of maintenance vedolizumab concentrations with remission.

机译：背景和AIMS Vedolizumab是溃疡性结肠炎[UC]和CrOHN病的抗-α4β7生物学。我们的旨在审查维持维多利瑞拉姆浓度与缓解的关联。

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《Journal of Crohn’s & colitis》 |2019年第8期|共7页
作者
Ungaro Ryan C.; Yarur Andres; Jossen Jacqueline; Phan Becky L.; Chefitz Ezra; Sehgal Priya; Kamal Kanika; Bruss Alexandra; Beniwal-Patel Poonam; Fox Caroline; Patel Amir; Bahur Bayda; Jain Anjali; Stein Daniel; Naik Snehal; Dubinsky Marla C.;
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作者单位

Icahn Sch Med Mt Sinai Susan &

Leonard Feinstein Inflammatory Bowel Dis New York NY 10029 USA;

Med Coll Wisconsin Madison WI USA;

Icahn Sch Med Mt Sinai Susan &

Leonard Feinstein Inflammatory Bowel Dis New York NY 10029 USA;

Icahn Sch Med Mt Sinai Susan &

Leonard Feinstein Inflammatory Bowel Dis New York NY 10029 USA;

Icahn Sch Med Mt Sinai Susan &

Leonard Feinstein Inflammatory Bowel Dis New York NY 10029 USA;

Icahn Sch Med Mt Sinai Susan &

Leonard Feinstein Inflammatory Bowel Dis New York NY 10029 USA;

Icahn Sch Med Mt Sinai Susan &

Leonard Feinstein Inflammatory Bowel Dis New York NY 10029 USA;

Med Coll Wisconsin Madison WI USA;

Med Coll Wisconsin Madison WI USA;

Med Coll Wisconsin Madison WI USA;

Med Coll Wisconsin Madison WI USA;

Prometheus Labs Inc San Diego CA USA;

Prometheus Labs Inc San Diego CA USA;

Med Coll Wisconsin Madison WI USA;

Prometheus Labs Inc San Diego CA USA;

Icahn Sch Med Mt Sinai Susan &

Leonard Feinstein Inflammatory Bowel Dis New York NY 10029 USA;

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原文格式 PDF
正文语种 eng
中图分类杆菌传染病;
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专利

1. Higher Trough Vedolizumab Concentrations During Maintenance Therapy are Associated With Corticosteroid-Free Remission in Inflammatory Bowel Disease [J] . Ungaro Ryan C., Yarur Andres, Jossen Jacqueline, Journal of Crohn’s & colitis . 2019,第8期

机译：维持治疗期间的高谷Vedolizumab浓度与炎性肠病的皮质类固醇缓解有关
2. Evidence to Support Monitoring of Vedolizumab Trough Concentrations in Patients With Inflammatory Bowel Diseases [J] . Erwin Dreesen, Bram Verstockt, Sumin Bian, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association . 2018,第12期

机译：支持对炎症性肠病患者的vedolizumab槽浓度进行支持的证据
3. Sustained Corticosteroid-Free Clinical Remission During Vedolizumab Maintenance Therapy in Patients with Ulcerative Colitis on Stable Concomitant Corticosteroids During Induction Therapy: A Post Hoc Analysis of GEMINI 1 [J] . Edward V Loftus Jr, Bruce E Sands, Jean-Frédéric Colombel, Clinical and Experimental Gastroenterology . 2020,第2期

机译：在诱导治疗期间溃疡性结肠炎患者溃疡性结肠炎患者患者持续的皮质类固醇临床缓解治疗：GEMINI 1的后HOC分析
4. Natural anti-Inflammatory Compounds for the Management and Adjuvant Therapy of Inflammatory Bowel Disease (IBD) and its Drug Delivery System(DDS) for Targeted to Colon. [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：用于炎症性肠病（IBD）的管理和佐剂治疗的天然抗炎化合物及其药物递送系统（DDS）用于靶向结肠。
5. Oxidation Status as a Predictor of Disease Activity and Response to Therapy in Pediatric Patients with Inflammatory Bowel Disease [D] . Ajithkumar, Aravindh K. 2020

机译：氧化地位作为疾病活动的预测因素，对炎症性肠病儿科患者的疗法响应
6. Higher Trough Vedolizumab Concentrations During Maintenance Therapy are Associated With Corticosteroid-Free Remission in Inflammatory Bowel Disease [O] . Ryan C Ungaro, Andres Yarur, Jacqueline Jossen, -1

机译：维持治疗期间的高谷Vedolizumab浓度与炎性肠病中的皮质类固醇缓解有关
7. Association of trough vedolizumab levels with clinical, biological and endoscopic outcomes during maintenance therapy in inflammatory bowel disease [O] . Nikolas Plevris, Philip W Jenkinson, Cher S Chuah, 2019

机译：炎症肠病维持治疗期间与临床，生物学和内窥镜结果的临床，生物学和内窥镜结果的关联

Higher Trough Vedolizumab Concentrations During Maintenance Therapy are Associated With Corticosteroid-Free Remission in Inflammatory Bowel Disease

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