Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies

Panes Julian; Vermeire Severine; Lindsay James O.; Sands Bruce E.; Su Chinyu; Friedman Gary; Zhang Haiying; Yarlas Aaron; Bayliss Martha; Maher Stephen; Cappelleri Joseph C.; Bushmakin Andrew G.; Rubin David T.

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Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies

机译：患有溃疡性结肠炎患者的TOFACITINIB：3期随机对照诱导和维护研究中的健康状生活质量

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Background and Aims: Tofacitinib is an oral, small molecule Janus kinase [JAK] inhibitor that is being investigated for ulcerative colitis [UC]. We evaluated health-related quality of life [HRQoL] in tofacitinib UC Phase 3 studies.

机译：背景和目的：Tofacitinib是一种口服，小分子Janus激酶[Jak]抑制剂，用于溃疡性结肠炎[UC]。我们评估了TOFACITINIB UC第3期研究中的健康相关的生活质量[HRQOL]。

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来源
《Journal of Crohn’s & colitis》 |2018年第2期|共12页
作者
Panes Julian; Vermeire Severine; Lindsay James O.; Sands Bruce E.; Su Chinyu; Friedman Gary; Zhang Haiying; Yarlas Aaron; Bayliss Martha; Maher Stephen; Cappelleri Joseph C.; Bushmakin Andrew G.; Rubin David T.;
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作者单位

Hosp Clin Barcelona IDIBAPS CIBERehd Barcelona Spain;

Univ Hosp Leuven Dept Gastroenterol Leuven Belgium;

Queen Mary Univ London Ctr Immunobiol Barts &

London Sch Med &

Dent London England;

Icahn Sch Med Mt Sinai Dr Henry D Janowitz Div Gastroenterol New York NY 10029 USA;

Pfizer Inc Collegeville PA USA;

Pfizer Inc Collegeville PA USA;

Pfizer Inc Collegeville PA USA;

Optum Lincoln RI USA;

Optum Lincoln RI USA;

Optum Lincoln RI USA;

Pfizer Inc Groton CT 06340 USA;

Pfizer Inc Groton CT 06340 USA;

Univ Chicago Med Ctr Inflammatory Bowel Dis Chicago IL 60637 USA;

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原文格式 PDF
正文语种 eng
中图分类杆菌传染病;
关键词
Patient-reported outcomes; quality of life; ulcerative colitis;

机译：患者报告的结果;生活质量;溃疡性结肠炎;

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专利

1. Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies (vol 24, pg 145, 2018) [J] . Panes Julian, Vermeire Severine, Lindsay James O., Journal of Crohn’s & colitis . 2019,第1期

机译：患有溃疡性结肠炎患者的Tofacitinib：3期随机对照诱导和维护研究中的健康相关生活质量（Vol 24，PG 145,2018）
2. Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies [J] . Motoya Satoshi, Watanabe Mamoru, Kim Hyo Jong, Intestinal research. . 2018,第2期

机译：东亚活动性溃疡性结肠炎患者的Tofacitinib诱导和维持治疗：来自三项三期跨国研究的亚组分析
3. Health-related quality of life and patient-centred outcomes with olaparib maintenance after chemotherapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT Ov-21): a placebo-controlled, phase 3 randomised trial [J] . Friedlander Michael, Gebski Val, Gibbs Emma, The lancet oncology . 2018,第8期

机译：在铂敏感，复发卵巢癌和BRCA1 / 2突变患者中，在化疗后，与奥拉帕里韦维持的健康相关的生活质量和患者为中心的结果（Solo2 / engot OV-21）：安慰剂控制，第3期随机试验
4. Synbiotic Therapy Significantly Reduces Molecular Markers of Inflammation and Clinical Scores in Patients with Active Ulcerative Colitis; A Randomised Controlled Trial [C] . Controlled Release Society annual meeting . 2004

机译：同步治疗显着减少了活性溃疡性结肠炎患者的炎症和临床评分的分子标记;随机对照试验
5. Quality of life of patients with mucosal ulcerative colitis following ileal pouch anal anastomosis surgery. [D] . Quinn Griffin, Mary Therese. 2001

机译：回肠袋肛门吻合手术后粘膜溃疡性结肠炎患者的生活质量。
6. Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies [O] . Julian Panés, Séverine Vermeire, James O Lindsay, -1

机译：托法替尼治疗溃疡性结肠炎：3期随机对照诱导和维持研究中与健康相关的生活质量
7. Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies [O] . Julian Panés, Séverine Vermeire, James O Lindsay, 2018

机译：患有溃疡性结肠炎患者的TOFACITINIB：3期随机控制诱导和维护研究中的健康状生活质量

Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomised Controlled Induction and Maintenance Studies

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