Efficient and relatively safe emulsification microextraction using a deep eutectic solvent for influential enrichment of trace main anti-depressant drugs from complicated samples

摘要

Graphical abstractDisplay OmittedHighlights?A new version of low-density solvent based emulsification microextraction was introduced for highly effective enrichment of three antidepressant drugs.?The influential extraction agent based on choline chloride was easily synthesized via a facile, safe, and mild route without need to further purification step.?Accurate analyses at trace levels close to therapeutic/potentially toxic ranges in human plasma were readily feasible.?Proper efficiency, notable simplicity, high speed, tolerable safety, and low cost are prominent features of this proposed extraction approach.?Optimization of main parameters impacts were efficiently accomplished through multivariate procedures.展开▼