Optimizing the antisepsis protocol: Effectiveness of 3 povidone-iodine 1.0% applications versus a single application of povidone-iodine 5.0%

摘要

Purpose: To determine the minimum effective concentration of povidone-iodine that reduces the bacterial load by 3-log(10), the U.S. Food and Drug Administration requirement for antiseptic agents, and to study alternative dosing schedules of povidone-iodine to optimize its bactericidal effect.