Strong/Weak Feature Recognition of Promoters Based on Position Weight Matrix and Ensemble Set-Valued Models

摘要

In this article, we propose a method to recognize the strong/ weak property of the promoters based on the nucleotide sequence. To the best of our knowledge, it is the first time to predict the strong/weak property of the promoters. First, position weight matrix (PWM) is used to evaluate the contributions of the nucleotides to the promoter strength. Then, the set-valued model is used to describe the relation between the nucleotide sequence and the strength. Considering the small-sample and imbalance features of the promoter data, we propose an ensemble approach to predict the strong/ weak property of the promoters. The proposed method is used to recognize 60 d E promoters of Escherichia coli. The results show the effectiveness of the proposed method. This article provides a simple way for a biologist to evaluate the strong/ weak feature of promoters from the nucleotide sequence.