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首页> 外文期刊>Journal of Chemical Technology & Biotechnology >In situIn situ base release for pHpH maintenance can allow shake flasks to better mimic bioreactor performance for CHOCHO cell culture
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In situIn situ base release for pHpH maintenance can allow shake flasks to better mimic bioreactor performance for CHOCHO cell culture

机译：原位为 pH pH维护可以允许摇动烧瓶为 cho cho细胞文化来更好地模仿生物反应器性能

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Abstract <section xml:id="jctb5635-sec-0001" numbered="no"> <title type="main" xml:lang="de">BACKGROUND > Shake flasks are widely used for evaluating mammalian cells in suspension. Lack of pH control can contribute to differences in culture performance between them and bioreactors. This study evaluates whether a previously reported <fi>in situ</fi> base releasing hydrogel (pHmH) to counter pH decrease can enable shake flask cultures to better mimic bioreactor cultures. </section> <section xml:id="jctb5635-sec-0002" numbered="no"> <title type="main">RESULTS >Compared with bioreactor culture, fed‐batch cultures of a recombinant Chinese hamster ovary (CHO) cell‐line in shake flasks without pHmH showed a decrease in pH to 6.6, accompanied by 40, 60 and 22% lower peak cell density, lactate accumulation, and immunoglobulin G (IgG) titer, respectively. Use of pHmH allowed shake flasks to maintain pH above 6.8 and reduced this difference to 20, 30, and 15%, respectively, thus enabling culture performance in shake flasks to better mimic the bioreactor. IgG glycosylation profiles were similar in identically fed cultures across all three platforms. Application of pHmH hydrogel during clone screening was evaluated by comparing correlation between titers for five recombinant CHO clones in bioreactors and shake flasks with and without pHmH; a higher correlation was found in shake flasks with pHmH than without. </section> <section xml:id="jctb5635-sec-0003" numbered="no"> <title type="main">CONCLUSION > <fi>In situ</fi> base release through hydrogel can allow identically fed fed‐batch cultures in shake flasks to better mimic cell growth, lactate accumulation and IgG titers </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> <section XML：ID =“JCTB5635-SEC-0001”编号=“否”> <标题类型=“main”XML：Lang =“de”>背景</标题> <P>摇瓶广泛用于评估悬浮中的哺乳动物细胞。缺乏pH控制可以有助于它们与生物反应器之间的培养性能的差异。该研究评估先前报道的<fi>原位</ fi>碱释放水凝胶（pHMH）以抵抗pH降低可以使摇动瓶培养物能够更好地模拟生物反应器培养物。 </ p> </ section> <section XML：ID =“JCTB5635-SEC-0002”编号=“否”> <标题类型=“main”>结果</ title> >与生物反应器文化相比 - 在没有PHMH的摇瓶中的重组中仓鼠卵巢（CHO）细胞系的分批培养物显示pH至6.6的降低，伴随40,60％和22％较低的峰值细胞密度，乳酸积累和免疫球蛋白G（IgG）滴度， 分别。使用PHMH允许摇瓶以保持在6.8以上，并分别将这种差异降低到20,30和15％，从而使摇动烧瓶中的培养性能能够更好地模仿生物反应器。 IgG糖基化曲线在所有三个平台上相似地喂养培养物。通过比较生物反应器中的五种重组Cho克隆的滴度与具有和不具有PHMH的摇匀瓶的滴度之间的相关性来评价PHMH水凝胶的施用。在具有PHMH的摇瓶中发现了更高的相关性。</ p> </段> <部分XML：ID =“JCTB5635-SEC-0003”编号=“否”> <标题类型=“main”>结论< /标题> > fi>原位</ fi>通过水凝胶的碱释放可以允许相同地喂养摇瓶中的填充培养物，以更好地模拟细胞生长，乳酸积累和IgG滴度 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-33908/'>《Journal of Chemical Technology & Biotechnology》</a> <b style="margin: 0 2px;">|</b><span>2018年第10期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Maralingannavar Vishwanathgouda&option=202" target="_blank" rel="nofollow">Maralingannavar Vishwanathgouda;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shenoy Bharath R&option=202" target="_blank" rel="nofollow">Shenoy Bharath R;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hazarika Jahnabi&option=202" target="_blank" rel="nofollow">Hazarika Jahnabi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Unnikrishnan Divya&option=202" target="_blank" rel="nofollow">Unnikrishnan Divya;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prabhu Anuja&option=202" target="_blank" rel="nofollow">Prabhu Anuja;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Maity Sunit&option=202" target="_blank" rel="nofollow">Maity Sunit;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gadgil Mugdha&option=202" target="_blank" rel="nofollow">Gadgil Mugdha;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Chemical Engineering and Process Development DivisionCSIR?–?National Chemical LaboratoryPune India;</p> <p>Upstream Process DevelopmentTheramyt NovobiologicsBengaluru India;</p> <p>Upstream Process DevelopmentTheramyt NovobiologicsBengaluru India;</p> <p>Upstream Process DevelopmentTheramyt NovobiologicsBengaluru India;</p> <p>Chemical Engineering and Process Development DivisionCSIR?–?National Chemical LaboratoryPune India;</p> <p>Upstream Process DevelopmentTheramyt NovobiologicsBengaluru India;</p> <p>Chemical Engineering and Process Development DivisionCSIR?–?National Chemical LaboratoryPune India;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a><a href="https://www.zhangqiaokeyan.com/clc/20827.html" title="生物化学过程">生物化学过程;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=in situ pH control&option=203" rel="nofollow">in situ pH control;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=shake flask&option=203" rel="nofollow">shake flask;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cell line development&option=203" rel="nofollow">cell line development;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=high throughput screening&option=203" rel="nofollow">high throughput screening;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=in situ base release&option=203" rel="nofollow">in situ base release;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=base addition&option=203" rel="nofollow">base addition;</a> </p> <div class="translation"> 机译：原位pH控制;摇瓶;细胞系发育;高吞吐量筛选;原位基本释放;贱民; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div 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