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Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single‐ and multi‐photon excitation of label free native molecules

机译：使用单次和多光子激发标记天然分子的单次和多光子激发来测量Alzheimer小鼠脑组织通过定位荧光光谱法测量

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Abstract > Time resolved spectroscopic measurements with single‐photon and multi‐photon excitation of native molecules were performed ex vivo on brain tissues from an Alzheimer's disease (AD) and a wild type (WT) mouse model using a streak camera. The fluorescence decay times of native NADH and FAD show a longer relaxation time in AD than in WT tissue, suggesting less non‐radiative processes in AD. The longer emission time of AD may be attributed to the coupling of the key native building block molecules to the amyloid‐tau and/or to the caging of the native fluorophores by the deposition of amyloid‐beta or tau plaques and neurofibrillary tangles that affect the local non‐radiative interactions. <blockFixed type="graphic"> <mediaResourceGroup> <mediaResource alt="image" href="urn:x-wiley:1864063X:media:jbio201600318:jbio201600318-toc-0001"/> </mediaResourceGroup> </blockFixed> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 进行具有单光子的分辨光谱测量和天然分子的多光子激发前vivo </ i> 在Alzheimer疾病（AD）和野生型（WT）小鼠模型的脑组织上使用连杆摄像机。天然NADH和FAD的荧光衰减时间在AD中显示比WT组织中的较长的弛豫时间，表明AD中的非辐射过程较少。 AD的较长发射时间可归因于将密钥天然建筑物块分子与淀粉样蛋白-Tau和/或通过沉积影响的淀粉样蛋白β或Tau斑块和神经纤维纤维缠结的耦合局部非辐射相互作用。 <blockfixed type =“图形”> <mediaresourcegroup> <MediareSource Alt =“Image”Href =“URN：X-Wiley：1864063x：媒体：JBIO201600318：JBIO201600318-TOC-0001”/> </ mediaresourcegroup> </ blockfixed> </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-33894/'>《Journal of Biophotonics》</a> <b style="margin: 0 2px;">|</b><span>2018年第1期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Das Bidyut&option=202" target="_blank" rel="nofollow">Das Bidyut;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shi Lingyan&option=202" target="_blank" rel="nofollow">Shi Lingyan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Budansky Yury&option=202" target="_blank" rel="nofollow">Budansky Yury;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rodriguez‐Contreras Adrian&option=202" target="_blank" rel="nofollow">Rodriguez‐Contreras Adrian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alfano Robert&option=202" target="_blank" rel="nofollow">Alfano Robert;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of PhysicsFairfield UniversityFairfield CT 06824 USA;</p> <p>Institute for Ultrafast Spectroscopy and LasersDepartment of Physics the City College of New YorkNew York NY 10031 USA;</p> <p>Institute for Ultrafast Spectroscopy and LasersDepartment of Physics the City College of New YorkNew York NY 10031 USA;</p> <p>Institute for Ultrafast Spectroscopy and LasersDepartment of Physics the City College of New YorkNew York NY 10031 USA;</p> <p>Institute for Ultrafast Spectroscopy and LasersDepartment of Physics the City College of New YorkNew York NY 10031 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/178.html" title="生物物理学">生物物理学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alzheimer disease&option=203" rel="nofollow">Alzheimer disease;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=time resolved fluorescence spectroscopy&option=203" rel="nofollow">time resolved fluorescence spectroscopy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=label free molecule&option=203" rel="nofollow">label free molecule;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=multiphoton excitation&option=203" rel="nofollow">multiphoton excitation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=brain optics&option=203" rel="nofollow">brain optics;</a> </p> <div class="translation"> 机译：Alzheimer病;时间分辨荧光光谱;标记免费分子;多光子刺激;脑光学; 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Zhu Bo</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱波&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,朱波</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhu Yong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Zhu Yong</a> <span> <a href="/conference-cn-39901/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2015年全国时间频率学术会议 </a> <span> <span> . 2015</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031642573.html">基于光子不可区分度测量单光子超短脉冲的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吕凡&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 吕凡</a> <span> . 2011</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" 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class="enjiyixqcontent" href="/patent-detail/06130407326140.html">LABEL-FREE SINGLE AND MULTI-PHOTON FLUORESCENCE SPECTROSCOPY TO DETECT BRAIN DISORDERS AND DISEASE: ALZHEIMER, PARKINSON AND AUTISM FROM BRAIN TISSUE, CELLS, SPINAL FLUID AND BODY FLUIDS</a> <b>[P]</b> . <span> 外国专利：  US2018078142A1 </span> <span> . 2018-03-22</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：无标签单光子和多光子荧光光谱法检测脑部疾病和疾病：脑组织，细胞，脊髓液和体液中的阿尔齐默，帕金森症和自闭症 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130409974540.html">Label-Free Single and Multi-Photon Fluorescence Spectroscopy to Detect Brain Disorders and Diseases: Alzheimer, Parkinson, and Autism From Brain Tissue, Cells, Spinal Fluid, and Body Fluids</a> <b>[P]</b> . <span> 外国专利：  US2017082640A1 </span> <span> . 2017-03-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：无标记的单光子和多光子荧光光谱法可检测脑部疾病和疾病：阿尔茨海默氏症，帕金森氏症和脑组织，细胞，脊髓液和体液的自闭症 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025419589','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p 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