Stereoselective Conversion of Dihydropyran and Glycals to 1 -Azido-2-halo Derivatives Using NIS/NBS-TMSN_3

摘要

Dihydropyran and glycals are readily converted to the corresponding trans-2-deoxy-2-haloazide derivatives in excellent yields within a few minutes using NIS/NBS-TMSN3 at rt in the absence of any catalyst. The use of stoichiometric amounts of the reagents under mild experimental conditions together with the simplicity of the reaction protocol is the notable feature of this transformation.