NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma

Sasahira Tomonori; Nishiguchi Yukiko; Kurihara-Shimomura Miyako; Nakashima Chie; Kuniyasu Hiroki; Kirita Tadaaki

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NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma

机译：含有1的NIPA样结构域是口腔鳞状细胞癌中的新型肿瘤促进因子

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Purpose In our previous global gene expression analysis, we identified NIPA-like domain containing 1 (NIPAL1), which encodes a magnesium transporter, as one of the most overexpressed genes in recurrent oral squamous cell carcinoma (OSCC). Although has been NIPAL1 linked with gout pathogenesis, little is known about its expression and function in human malignancies.

机译：目的在我们以前的全局基因表达分析中，我们鉴定了含有1（NiP1）的NIPA样结构域，其编码镁转运蛋白，作为复发口腔鳞状细胞癌（OSCC）中最过表达的基因之一。虽然是与痛风发病机制相关的否则，但对人类恶性肿瘤的表达和功能很少。

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来源
《Journal of Cancer Research and Clinical Oncology》 |2018年第5期|共8页
作者
Sasahira Tomonori; Nishiguchi Yukiko; Kurihara-Shimomura Miyako; Nakashima Chie; Kuniyasu Hiroki; Kirita Tadaaki;
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作者单位

Nara Med Univ Dept Mol Pathol 840 Shijo Cho Kashihara Nara 6348521 Japan;

Nara Med Univ Dept Mol Pathol 840 Shijo Cho Kashihara Nara 6348521 Japan;

Nara Med Univ Dept Mol Pathol 840 Shijo Cho Kashihara Nara 6348521 Japan;

Nara Med Univ Dept Oral &

Maxillofacial Surg Kashihara Nara Japan;

Nara Med Univ Dept Mol Pathol 840 Shijo Cho Kashihara Nara 6348521 Japan;

Nara Med Univ Dept Oral &

Maxillofacial Surg Kashihara Nara Japan;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
NIPAL1; Oral cancer; Intravasation; Prognosis;

机译：nial1;口腔癌;静物;预后;

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1. NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma [J] . Sasahira Tomonori, Nishiguchi Yukiko, Kurihara-Shimomura Miyako, Journal of Cancer Research and Clinical Oncology . 2018,第5期

机译：含有1的NIPA样结构域是口腔鳞状细胞癌中的新型肿瘤促进因子
2. Selective inhibition of nuclear factor-κB by nuclear factor-κB essential modulator-binding domain peptide suppresses the metastasis of highly metastatic oral squamous cell carcinoma. [J] . Takuya Tanaka, Hideki Nakayama, Yoshihiro Yoshitake, Cancer science. . 2012,第3期

机译：核因子-κB必需调节剂结合域肽对核因子-κB的选择性抑制可抑制高转移性口腔鳞状细胞癌的转移。
3. Selective inhibition of nuclear factor‐κB by nuclear factor‐κB essential modulator‐binding domain peptide suppresses the metastasis of highly metastatic oral squamous cell carcinoma [J] . Akimitsu Hiraki, Atsushi Irie, Hideki Nakayama, Cancer science. . 2012,第3期

机译：核因子-κB必需调节剂结合域肽对核因子-κB的选择性抑制可抑制高转移性口腔鳞状细胞癌的转移
4. The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 (Iressa) Suppresses Proliferation and Invasion of Human Oral Squamous Carcinoma Cells via p53 Independent and MMP, uPAR Dependent Mechanism [C] . EUN JU LEE, JIN HA WHANG, NAM KYEONG JEON, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：表皮生长因子受体酪氨酸激酶抑制剂ZD1839（Iressa）通过独立于p53和MMP，uPAR依赖性机制抑制人口腔鳞状细胞癌细胞的增殖和侵袭
5. Insulin-like growth factor binding protein-2: Contributions of the C-terminal domain to IGF binding and role in oral and oropharyngeal squamous cell carcinoma. [D] . Kibbey, Megan Marie. 2008

机译：胰岛素样生长因子结合蛋白2：C端结构域对IGF结合的贡献以及在口腔和口咽鳞状细胞癌中的作用。
6. Sushi Repeat Containing Protein X-linked 2 Is a Downstream Signal of LEM Domain Containing 1 and Acts as a Tumor-Promoting Factor in Oral Squamous Cell Carcinoma [O] . Tomonori Sasahira, Miyako Kurihara-Shimomura, Yukiko Nishiguchi, 2020

机译：Sushi重复包含蛋白质X连锁2是LEM域包含1的下游信号并作为口腔鳞状细胞癌的肿瘤促进因子。
7. Selective inhibition of nuclear factor-κB by nuclear factor-κB essential modulator-binding domain peptide suppresses the metastasis of highly metastatic oral squamous cell carcinoma [O] . Takuya Tanaka, Hideki Nakayama, Yoshihiro Yoshitake, 2012

机译：核因子-κB基本调节剂结合结构域肽选择性抑制核因子-κB抑制高度转移性口腔鳞状细胞癌的转移

NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma

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