Exercise Training in Patients With Non-Small Cell Lung Cancer During In-Hospital Chemotherapy Treatment A RANDOMIZED CONTROLLED TRIAL

摘要

Purpose: The aim of this study was to perform a randomized trial to assess the impact of exercise training in patients with non- small cell lung cancer during chemotherapy on several outcomes in comparison to a control group (CG). Methods: The exercise training group (ETG) consisted of 20 patients and the CG consisted of 10 patients. In the ETG, a 4- wk in- hospital exercise training program was performed in 2- wk cycles interspersed with consecutive rounds of chemotherapy with cytostatic drugs. The exercise training program was individualized and included warm- up, respiratory muscle exercise, training on a cycle ergometer or treadmill, and Nordic walking. CG participants were assessed before and after 6 wk of chemotherapy alone. Results: Comparing pre- and post- intervention values, the ETG demonstrated an increase in 6- min walk distance (486 +/- 92 vs 531 +/- 103 m, P =.01). In a battery of physical performance tests: Up and Go Test (6.3 +/- 1.0 vs 6.0 +/- 1.1 sec, P =.01); chair stand (13.3 +/- 2.8 vs 14.3 +/- 3.4 repetitions, P =.001); and arm curl (18.4 +/- 3.1 vs 20.4 +/- 3.5 repetitions, P =.001) all improved significantly. Spirometry values also improved: FEV1 % predicted (76 +/- 16 vs 84 +/- 15, P =.01), FVC % predicted (87 +/- 14 vs 95 +/- 13, P =.01), and FEV1/FVC (73 +/- 13% vs 76 +/- 12%, P =.04). The exercise training was well tolerated, without any adverse events due to exercise. There were no significant improvements in the CG.Conclusions: This study suggests that planned, individualized, and supervised exercise programs in patients with advanced lung cancer during chemotherapy are a practical and beneficial intervention for enhancing mobility and physical fitness.