...
首页> 外文期刊>Journal of cardiology >Significance of the antioxidant factor, thioredoxin, in heart failure
【24h】

Significance of the antioxidant factor, thioredoxin, in heart failure

机译:抗氧化因子,硫氧化素,心力衰竭的意义

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

OBJECTIVES: Increases in oxidative stress may be involved in the progression of heart diseases. However, the serum levels of thioredoxin, a redox regulating protein, have been poorly investigated in patients with heart diseases. This study evaluated the clinical significance of the serum thioredoxin levels in patients with heart failure. METHODS: The serum thioredoxin levels were determined with a sandwich enzyme-linked immunosorbent assay in a total of 34 patients with dilated cardiomyopathy (n = 5), acute coronary syndrome (n = 7), and stable angina (n = 18), including effort angina (n = 7) and vasospastic angina (n = 11), and control subjects (n = 4). RESULTS: The serum thioredoxin levels were significantly elevated in patients with acute coronary syndrome (30.6 +/- 4.9 ng/ml, p < 0.001) and dilated cardiomyopathy (36.9 +/- 8.6 ng/ml, p < 0.001), but not in patients with stable angina (16.8 +/- 5.7 ng/ml, p = 0.27) compared with the control subjects (n = 4, 13.0 +/- 4.9 ng/ml). The serum thioredoxin level in patients with III and IV functional classes of the New York Heart Association (n = 8, 33.3 +/- 8.6 ng/ml, p < 0.001) was significantly higher than in the control subjects. In addition, the serum thioredoxin levels were negatively correlated with left ventricular ejection fractions of the patients (r = 0.59, p < 0.001). CONCLUSIONS: These results indicate a possible association between thioredoxin and the severity of heart failure.
机译:目的:氧化应激的增加可能涉及心脏病的进展。然而,心脏病患者患有氧化还原调节蛋白的血清毒素水平较差。该研究评估了心力衰竭患者血清硫氧化肽水平的临床意义。方法:用夹层酶联免疫吸附测定法测定血清硫氧肽水平,共34例扩张心肌病(n = 5),急性冠状动脉综合征(n = 7),稳定的心绞痛(n = 18),包括努力心绞痛(n = 7)和旋转痉挛(n = 11)和对照受试者(n = 4)。结果:急性冠状动脉综合征患者(30.6 +/- 4.9 ng / ml,p <0.001)和扩张的心肌病(36.9 +/- 8.6ng / ml,p <0.001),但不升高血清毒素水平显着升高与对照受试者相比,稳定心绞痛(16.8 +/- 5.7ng / ml,p = 0.27)(n = 4,13.0 +/- 4.9ng / ml)。 III和IV型功能类别患者血清硫氧化素水平(n = 8,33.3 +/- 8.6ng / ml,p <0.001)显着高于对照组。此外,血清硫酸素水平与患者的左心室喷射部分负相关(r = 0.59,p <0.001)。结论:这些结果表明患有毒素与心力衰竭严重程度之间的可能关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号