Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

摘要

We examined whether neuropsychiatric symptoms (NPS) interact with cerebrospinal fluid (CSF) biomarkers (amyloid-beta(42) [A beta(42)], tau, phosphorylated tau(181) [ptau(181)], tau/A beta(42), and ptau(181)/A beta(42)) of Alzheimer's disease pathology to predict driving decline among cognitively-normal older adults (N= 116) aged >= 65. Cox proportional hazards models examined time to receiving a rating of marginal or fail on the driving test. Age, education, and gender were adjusted in the models. Participants with more abnormal CSF (A beta(42), tau/A beta(42), ptau(181)/A beta(42)) and NPS were faster to receive a marginal/fail on the road test compared to those without NPS. NPS interact with abnormal CSF biomarkers to impact driving performance among cognitively-normal older adults.