Cymbopogon flexuosus Leaves Mediated Synthesis of ZnO Nanoparticles: Cytotoxicity Assay Against THP-1 Human Leukemia Cell Line

摘要

Biological synthesis of different nanoparticles and their applications especially in the fields of biomedical sciences are gaining prominence nowadays due to their handy and reproducible synthetic protocols which are cost-effective and eco-friendly. In this work, biosynthesis of zincoxide nanoparticles (ZnO NPs) using 50% acetone extract of lemon grass (Cymbopogon flexuosus ) has been presented. Formation of ZnO NPs was ascertained from X-ray diffraction and scanning electron microscopic studies. The cytotoxic potential of ZnO NPs was ascertained against the THP-1human leukemia cells by studying the intracellular ROS generation levels and MTT assay which have been compared with untreated cells. Lemon grass synthesized ZnO NPs showed enhanced ROS levels, inhibited cell proliferation and prominent cytotoxicity against THP-1 leukemia cells which indicatedits potential in future cancer treatment.