The Need of a Paradigm Shift to Better Understand PiT1 and PiT2 Biology: Response to “Why Is There No PiT1/SLC20A1 Pathogenic Variants Yet Linked to Primary Familial Brain Calcification?”

Beck‐Cormier Sarah; Beck Laurent

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The Need of a Paradigm Shift to Better Understand PiT1 and PiT2 Biology: Response to “Why Is There No PiT1/SLC20A1 Pathogenic Variants Yet Linked to Primary Familial Brain Calcification?”

机译：需要一个范式转变以更好地了解PIT1和PIT2生物学：回应“为什么没有PIT1 / SLC20A1致病变体与主要家族脑钙化有关？”

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《Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research》 |2020年第4期|共2页
作者
Beck‐Cormier Sarah; Beck Laurent;
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作者单位

Université de NantesINSERM UMR 1229 RMeS ONIRISNantes France;

Université de NantesINSERM UMR 1229 RMeS ONIRISNantes France;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
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1. The Need of a Paradigm Shift to Better Understand PiT1 and PiT2 Biology: Response to “Why Is There No PiT1/SLC20A1 Pathogenic Variants Yet Linked to Primary Familial Brain Calcification?” [J] . Beck‐Cormier Sarah, Beck Laurent Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2020,第4期

机译：需要一个范式转变以更好地了解PIT1和PIT2生物学：回应“为什么没有PIT1 / SLC20A1致病变体与主要家族脑钙化有关？”
2. Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival [J] . Sampada Chande, Daniel Caballero, Bryan B. Ho, Scientific reports. . 2020,第1期

机译：SLC20A1 / PIT1和SLC20A2 / PIT2对于正常的骨骼MyoFiber功能和生存至关重要
3. Primary Brain Calcification Causal PiT2 Transport-Knockout Variants can Exert Dominant Negative Effects on Wild-Type PiT2 Transport Function in Mammalian Cells [J] . Larsen Frederik Tibert, Jensen Nina, Autzen Jacob Kwasi, Journal of Molecular Neuroscience: MN . 2017,第2期

机译：原发性脑钙化因果关系PIT2运输敲除变体可以对哺乳动物细胞中的野生型PIT2运输功能产生显性负面影响
4. Phosphate (Pi)-regulated heterodimerization of the high-affinity sodium-dependent Pi transporters PiT1/Slc20a1 and PiT2/Slc20a2 underlies extracellular Pi sensing independently of Pi uptake [O] . Nina Bon, Greig Couasnay, Annabelle Bourgine, 2018

机译：磷酸（Pi）调控的高亲和力钠依赖性Pi转运蛋白PiT1 / Slc20a1和PiT2 / Slc20a2的异二聚作用是细胞外Pi感应的基础与Pi的吸收无关
5. The Need of a Paradigm Shift to Better Understand PiT1 and PiT2 Biology: Response to “Why Is There No PiT1/SLC20A1 Pathogenic Variants Yet Linked to Primary Familial Brain Calcification?” [O] . Sarah Beck‐Cormier, Laurent Beck 2020

机译：需要一个范式转变以更好地了解PIT1和PIT2生物学：回应“为什么没有PIT1 / SLC20A1致病变体与主要家族脑钙化有关？”

The Need of a Paradigm Shift to Better Understand PiT1 and PiT2 Biology: Response to “Why Is There No PiT1/SLC20A1 Pathogenic Variants Yet Linked to Primary Familial Brain Calcification?”

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