The Results of Endolymphatic Antibacterial Therapy in the Postoperative Period of Chronic Odontogenic Osteomyelitis of the Mandible

摘要

Surgery for severe chronic or atypical ongoing purulent-inflammatory diseases of the face and neck is performed alongside antibacterial therapy. We proposed the treatment of severe forms of the chronic stage of odontogenic osteomyelitis of the mandible using the method of direct intra-arterial lymphotropic therapy through the superficial temporal artery on the side of the lesion. The purpose of this study was to determine the concentration of antibiotic in the blood serum, flowing from the patient'smandible from the localization of the focus of pathology when the traditional (intravenous) and intra-arterial routes of administration are used during postoperative period of chronic odontogenic osteomyelitis of the mandible. Comparison of the concentration of "Amoxiclave" within two methods of administration shows that the intra-arterial pathway leads to a rapid emergence and maintenance of high concentrations of antibiotic in the blood serum flowing from the lesion focus. After 30 minutes of observation, the level of "Amoxiclav" with intravenous administration was lower by 31.0%, and after 24 hours - by 35.4%.