SULFAMIC ACID-CATALYZED CONVERSION OF o-AMINOTHIOPHENOL AND AROMATIC ALDEHYDES TO 2-ARYLBENZOTHIAZOLES

摘要

Non-metallic, non-toxic, and cheap sulfamic acid was used as a catalyst for the synthesis of 2-arylbenzothiazole from o-aminothiophenol and aromatic aldehydes bearing electron-donating or electron-withdrawing groups. The sulfamic acid catalyst can be reused without any change in catalytic effect. The drug GW610 was successfully synthesized on a hundred-gram scale using this synthetic route.