SYNTHESIS OF NITROGEN CONTAINING HETEROCYCLES BY USING CARBON-NITROGEN DOUBLE BOND

摘要

Recent achievements in the construction of mainly nitrogen containing heterocycles by the intramolecular cyclization of alkenylanilides via activation of unsaturated bonds are reviewed. NIS or ZnX2 activation of 2-alkenylanilines and 2-alkynylanilines gave quinolines or indoles in high yields. Reaction of 2-aminobenzaldehyde with acetophenones under basic conditions gave dibenzonaphthyridines in one-pot operation. Other nitrogen and chalcogene containing heterocycles were also synthesized by the reaction of ketone hydrazones with chalcogen halides.