PALLADIUM-CATALYZED ONE-POT APPROACH TO 3-(1,3-DIARYLPROP-2-YN-1-YLIDENE)OXINDOLES

摘要

An efficient and stereoselective one-pot approach for synthesizing 3-(1,3-diarylprop-2-yn-1-ylidene)oxindoles has been developed, starting from propiolamide, aryl iodides and arylacetylenes and utilizing two palladium-catalyzed reactions: the Sonogashira and Heck reactions. This method produced (E)-3-(1,3 -diarylprop-2-yn-1-ylidne)oxindoles as the major stereoisomers. This is the first time an effective synthetic method for (E)-isomer of these compounds has been reported.