CONCISE SYNTHESIS OF AZAFLUORENONE AND ITS APPLICATION TO INDENO[1,2-c]ISOQUINOLONE

摘要

The total synthesis of azafluorenone alkaloid, an onychine isolated from Onychopetalum amazonicum, was newly achieved by constructing an azafluorene framework using thermal electrocyclization of the aza 6 pi-electron system. This methodology was applied for the synthesis of indeno[1,2-c]isoquinolones as an attractive scaffold for developing anticancer agents.