Heterogeneous HIV-1 Reactivation Patterns of Disulfiram and Combined Disulfiram plus Romidepsin Treatments

摘要

Objectives: Few single latency-reversing agents (LRAs) have been tested in vivo, and only some of them have demonstrated an effect, albeit weak, on the decrease of latent reservoir. Therefore, other LRAs and combinations of LRAs need to be assessed. Here, we evaluated the potential of combined treatments of therapeutically promising LRAs, disulfiram and romidepsin.