Transdermal Delivery of Diltiazem Hydrochloride from Poloxamer-HPMC Gel: in vitro, ex vivo, and in vivo Studies

摘要

Background: Hypertension is the most common cardiovascular disease worldwide and number one cause of death. Its related morbidities also impose huge economic burdens on population. The aim of the present investigation was to prepare thermal gel of Diltiazem Hydrochloride (DTZ) with different ratios of Poloxamer 407 (PLM 407) and Hydroxypropyl methylcellulose K100M (HPMC K100M) and to characterize their in vitro parameters, ex vivo permeation and in vivo anti-hypertensive activity.