Improved Skin Penetration of Hydrophobic Glycyrrhetinic Acid Smart- Crystal? Compared to Its Water Soluble Salt

Mishra Moumita; Shegokar Ranjita; Gohla Sven; Muller Rainer H.

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Improved Skin Penetration of Hydrophobic Glycyrrhetinic Acid Smart- Crystal? Compared to Its Water Soluble Salt

机译：改善了疏水性甘草酸智能晶体的皮肤渗透性？与水溶性盐相比

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机译：<！[CDATA [目的和目标：本研究的目的是评估水不溶性甘草酸（GHA）纳米晶体的皮肤渗透性能与水溶性甘草酸盐（GA）的凝胶和O / W纳米乳液制剂相比。方法：GHA-Smartcrystal？使用珠粒研磨，然后高压均质化制备。通过均化制备纳米晶体和O / W纳米乳液。测试所有制剂的体外渗透和体内渗透性能。结果与讨论：Smartcrystal？和O / W纳米乳液分别具有158nm和183nm的平均粒径。配方的Zeta电位值约为-30 mV，表明具有良好的物理稳定性。 24小时后，累积的体外皮肤渗透为3.29＆＃956; g / cm2,7.13＆＃956; g / cm2,4.24＆＃956; g / cm 2和3.64＆＃956; g / cm2或gha-粗悬浮液，Smartcrystal？，O / W纳米乳剂和Ga-Gel，分别在猪耳皮中。从胶带中恢复的累积活性的累积量为4.52＆＃956; g / cm2,93.24＆＃956; g / cm2,9.64＆＃956; g / cm2和5.55＆＃956; g / cm2为gha粗悬架， Smartcrystal？，Ga-O / W纳米乳液和Ga-Gel，分别表明开发纳米晶体的优异性能。结论：在体外和体内测试时，Smartcrystals和纳米晶体显示出更高的累积药物渗透。 Smartcrytals由于较小的尺寸和增强的渗透性，因此提供了卓越的GHA性能。 Smartcrytals可以很容易地混合任何局部或皮肤剂量载体，如凝胶，奶油或乳液，以便于应用。

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《Drug delivery letters》 |2017年第3期|共8页
作者
Mishra Moumita; Shegokar Ranjita; Gohla Sven; Muller Rainer H.;
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正文语种 eng
中图分类药学;
关键词
milling; in vivo tape stripping study; nanocrystals; glycyrrhizic acid (GA); SmartCrystal?; high pressure homogenization (HPH) in vitro skin penetration; Glycyrrhetinic acid (GHA);

机译：铣削;体内胶带剥离研究;纳米晶体;甘草酸（GA）;Smartcrystal？;高压均质化（HPH）体外皮肤渗透;甘草酸（GHA）;

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1. Improved Skin Penetration of Hydrophobic Glycyrrhetinic Acid Smart- Crystal? Compared to Its Water Soluble Salt [J] . Mishra Moumita, Shegokar Ranjita, Gohla Sven, Drug delivery letters . 2017,第3期

机译：改善了疏水性甘草酸智能晶体的皮肤渗透性？与水溶性盐相比
2. Click strategy using disodium salts of amino acids improves the water solubility of plinabulin and KPU-300 [J] . Yakushiji Fumika, Muguruma Kyohei, Hayashi Yoshiki, Bioorganic and medicinal chemistry . 2017,第14期

机译：点击氨基酸二盐盐的策略改善了Plinabulin和KPU-300的水溶性
3. Lidocaine self-sacrificially improves the skin permeation of the acidic and poorly water-soluble drug etodolac via its transformation into an ionic liquid [J] . Miwa Yasushi, Hamamoto Hidetoshi, Ishida Tatsuhiro European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2016,第Null期

机译：利多卡因可自我转化为离子液体，从而可自我改善酸性和水溶性差的依托度酸的皮肤渗透性
4. Effect of Salt on the Viscosity and Microstructure of Hydrophobically Associating Water-soluble Polymer [C] . RUI Zhang, NI Qin, BINGYAN Hu, International Conference on Energy, Environment and Sustainable Development . 2012

机译：盐对疏水性缔合水溶性聚合物粘度和微观结构的影响
5. Two studies on self-assembly of amphiphilic molecules: (1) 3-dimensional assembly of hydrophobically modified water soluble polymer (HMWSP); (2) 2-dimensional assembly of surfactants at the solid/water and air/water interfaces. [D] . Kumar, Vikram. 1997

机译：两性分子自组装的两项研究：（1）疏水改性水溶性聚合物（HMWSP）的3维组装；（2）表面活性剂在固体/水和空气/水界面的二维组装。
6. Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug [O] . Fengbo Wu, Ting Xu, Chi Liu, 2013

机译：甘草次酸-聚（乙二醇）-甘草次酸三嵌段共轭胶束的自组装胶束用于肝靶向输送水溶性差的药物
7. Studies on the reduction of salt concentration in fermented foods Part XIII. Amino acids of water soluble and butanol soluble fractions from non-salted and several kinds of soybean miso. [O] . Yasuji OKADA, Naohiko YAMAGUCHI, Hisao YOSHII 1990

机译：发酵食品中盐浓度减少的研究XIII。来自非盐酸和几种大豆味噌水溶性和丁醇可溶性级分的氨基酸。
8. Water-Soluble Copolymers. 53. (23)Na NMR Studies of Hydrophobically-ModifiedPolyacids: Copolymers of 2-(1-Naphthylacetamido) ethylacrylamide with Acrylic Acid and Methacrylic Acid [R] . Newman, J. K., McCormick, C. L. 1994

机译：水溶性共聚物。 53.（23）疏水改性多酸的Na NmR研究：2-（1-萘基乙酰氨基）乙基丙烯酰胺与丙烯酸和甲基丙烯酸的共聚物

Improved Skin Penetration of Hydrophobic Glycyrrhetinic Acid Smart- Crystal? Compared to Its Water Soluble Salt

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