Synthesis of Deuterated or Tritiated Glycine and Its Methyl Ester

摘要

Heating glycine (Gly) and methyl glycinate (GlyOCH(3)) supported on 5% Pd/C or 5% Pt/C in a deuterium or tritium gas atmosphere gave the isotope-labeled products. The experiments were carried out at 180 degrees C for 10 min. The deuterium atom inclusion under these conditions averaged up to 1.8 atoms per molecule for Gly and up to 1.0 atom per molecule for GlyOCH(3). The reaction with tritium gas gave labeled products with a specific radioactivity of 27-31 Ci/mmol for Gly and 18 Ci/mmol for GlyOCH(3).