A first-in-human phase I/II trial demonstrates the safety and the immunogenicity of a lentiviral-based therapeutic HIV vaccine eliciting potent polyfunctional multispecific CD8 and CD4 T-cell responses in HIV-infected individuals

Toussaint H.; Agaugue S.; Sarry E.; Bejanariu A.; Sabbah-Petrover E.; Bauche C.

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A first-in-human phase I/II trial demonstrates the safety and the immunogenicity of a lentiviral-based therapeutic HIV vaccine eliciting potent polyfunctional multispecific CD8 and CD4 T-cell responses in HIV-infected individuals

机译：第一阶段I / II试验证明了致脂素治疗艾滋病毒疫苗引发艾滋病毒感染的个体中的慢病毒的治疗性HIV疫苗的安全性和免疫原性

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来源
《Human gene therapy》 |2015年第10期|共1页
作者
Toussaint H.; Agaugue S.; Sarry E.; Bejanariu A.; Sabbah-Petrover E.; Bauche C.;
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Theravectys Villejuif France;

Theravectys Villejuif France;

Theravectys Villejuif France;

Theravectys Villejuif France;

Theravectys Villejuif France;

Theravectys Villejuif France;

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正文语种 eng
中图分类治疗学;
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1. A first-in-human phase I/II trial demonstrates the safety and the immunogenicity of a lentiviral-based therapeutic HIV vaccine eliciting potent polyfunctional multispecific CD8 and CD4 T-cell responses in HIV-infected individuals [J] . Toussaint H., Agaugue S., Sarry E., Human gene therapy . 2015,第10期

机译：第一阶段I / II试验证明了致脂素治疗艾滋病毒疫苗引发艾滋病毒感染的个体中的慢病毒的治疗性HIV疫苗的安全性和免疫原性
2. Lessons from IAVI-006, a Phase I clinical trial to evaluate the safety and immunogenicity of the pTHr.HIVA DNA and MVA.HIVA vaccines in a prime-boost strategy to induce HIV-1 specific T-cell responses in healthy volunteers [J] . Guimaraes-Walker A., Mackie N., McCormack S., Vaccine . 2008,第51期

机译：IAVI-006的经验教训，I期临床试验旨在评估pTHr.HIVA DNA和MVA.HIVA疫苗在健康志愿者中诱导HIV-1特异性T细胞应答的初免-加强策略的安全性和免疫原性
3. CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8(+) T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals. [J] . Liu J, Yu Q, Stone GW, Vaccine . 2008,第32期

机译：从金丝雀痘载体ALVAC表达的CD40L可以增强小鼠中HIV-1金丝雀痘疫苗的免疫原性，并增强HIV-1感染者和HIV-1未感染者的病毒特异性CD8（+）T细胞记忆反应的体外扩展。
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens [O] . Julien Nyombayire, Omu Anzala, Brian Gazzard, -1

机译：鼻内复制能力增强的仙台病毒载体HIV 1型gag疫苗的安全性和免疫原性的首次人类评估：初次加强免疫方案中诱导的强力T细胞或抗体应答
6. Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [O] . Klaus Reither, Lynn Katsoulis, Trevor Beattie, 2014

机译：H1 /IC31®，一种佐剂结核亚单位疫苗的安全性和免疫原性，用于CD4 +淋巴细胞计数大于350个细胞/ mm3的HIV感染成人：II期，多中心，双盲，随机，安慰剂对照试验。
7. Randomized Double-Blind Phase III Pivotal Field Trial of the Comparative Immunogenicity Safety and Tolerability of Two Yellow Fever 17D Vaccines (ARILVAX(Trademark) and YF-VAX(Trademark)) in Healthy Infants and Children in Peru [R] . Belmusto-Worn, V. E. , Sanchez, J. L. , McCarthy, K. , 2004

机译：秘鲁健康婴儿和儿童两种黄热病17D疫苗（aRILVaX（商标）和YF-VaX（商标））的比较免疫原性安全性和耐受性的随机双盲III期关键现场试验

A first-in-human phase I/II trial demonstrates the safety and the immunogenicity of a lentiviral-based therapeutic HIV vaccine eliciting potent polyfunctional multispecific CD8 and CD4 T-cell responses in HIV-infected individuals

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