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Resting‐state amplitude of low‐frequency fluctuation is associated with suicidal ideation

机译：低频波动的休息状态幅度与自杀式念头有关

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Abstract <section xml:id="da22888-sec-0010" numbered="no"> <title type="main">Background >Identifying brain activity patterns that are associated with suicidal ideation (SI) may help to elucidate its pathogenesis and etiology. Suicide poses a significant public health problem, and SI is a risk factor for suicidal behavior. </section> <section xml:id="da22888-sec-0020" numbered="no"> <title type="main">Methods >Forty‐one unmedicated adult participants in a major depressive episode (MDE), 26 with SI on the Beck Scale for Suicidal Ideation and 15 without SI, underwent resting‐state functional magnetic resonance imaging scanning. Twenty‐one healthy volunteers (HVs) were scanned for secondary analyses. Whole brain analysis of both amplitude of low‐frequency fluctuations (ALFFs) and fractional ALFF was performed in MDE subjects to identify regions where activity was associated with SI. </section> <section xml:id="da22888-sec-0030" numbered="no"> <title type="main">Results >Subjects with SI had greater ALFF than those without SI in two clusters: one in the right hippocampus and one in the thalamus and caudate, bilaterally. Multi‐voxel pattern analysis distinguished between those with and without SI. Post hoc analysis of the mean ALFF in the hippocampus cluster found it to be associated with a delayed recall on the Buschke memory task. Mean ALFF from the significant clusters was not associated with depression severity and did not differ between MDE and HV groups. </section> <section xml:id="da22888-sec-0040" numbered="no"> <title type="main">Discussion >These results indicate that SI is associated with altered resting‐state brain activity. The pattern of elevated activity in the hippocampus may be related to how memories are pr </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：lang =“en”> <标题类型=“main”>抽象</ title> <section xml：id =“da22888-sec-0010”编号=“否”> <标题类型=“Main”>背景>背景</标题> >识别与自杀念头（Si）相关的脑活动模式可能有助于阐明其发病机制和病因。自杀构成了重要的公共卫生问题，SI是自杀行为的危险因素。</ p> </ section> <secto xml：id =“da22888-sec-0020”编号=“否”> <标题类型=“主要“>方法</ title> >在一个主要抑郁情节（MDE）中的四十一点成人参与者，26个，SI在贝克鳞片上进行自杀式展示和15，没有SI，接受休息状态磁共振成像扫描。为二次分析扫描二十一匹健康志愿者（HVS）。在MDE受试者中进行了低频波动（ALFF）和分数ALFF的全大脑分析，以识别活动与SI相关活动的区域。</ p> </ section> <section XML：ID =“DA22888-SEC -0030“编号=”否“> <标题类型=”main“>结果</ title> >与si的主题比在两个集群中没有si的那些my更大的ALFF：一个在右边海马和丘脑中的一个凯特，双边。多体素图案分析区分，有没有Si的那些。 Hoc在海马集群中的平均ALFF的后HOC分析发现它与BusChke内存任务的延迟召回相关联。来自显着簇的平均alff与抑制严重程度无关，MDE和HV组之间没有差异。</ p> </ section> <secto xml：id =“da22888-sec-0040”编号=“否”> <标题类型=“main”>讨论</ title> >这些结果表明si与改变的休息状态大脑活动相关联。海马中升高的活动模式可能与记忆如何是pr </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2019年第5期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lan Martin J.&option=202" target="_blank" rel="nofollow">Lan Martin J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rizk Mina M.&option=202" target="_blank" rel="nofollow">Rizk Mina M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pantazatos Spiro P.&option=202" target="_blank" rel="nofollow">Pantazatos Spiro P.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rubin‐Falcone Harry&option=202" target="_blank" rel="nofollow">Rubin‐Falcone Harry;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Miller Jeffrey M.&option=202" target="_blank" rel="nofollow">Miller Jeffrey M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sublette M. Elizabeth&option=202" target="_blank" rel="nofollow">Sublette M. Elizabeth;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oquendo Maria A.&option=202" target="_blank" rel="nofollow">Oquendo Maria A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Keilp John G.&option=202" target="_blank" rel="nofollow">Keilp John G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mann J. John&option=202" target="_blank" rel="nofollow">Mann J. John;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> <p>Department of PsychiatryPerelman School of MedicinePhiladelphia Pennsylvania;</p> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> <p>Department of PsychiatryColumbia University College of Physicians and SurgeonsNew York New York;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biomarker&option=203" rel="nofollow">biomarker;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fMRI&option=203" rel="nofollow">fMRI;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=major depressive disorder&option=203" rel="nofollow">major depressive disorder;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=resting state&option=203" rel="nofollow">resting state;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=suicide&option=203" rel="nofollow">suicide;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=suicidal ideation&option=203" rel="nofollow">suicidal ideation;</a> </p> <div class="translation"> 机译：生物标志物;FMRI;主要抑郁症;休息状态;自杀;自杀意念; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李洪强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李洪强</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姚艳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,姚艳</a> <span> <a href="/journal-cn-6239/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 神经损伤与功能重建 </a> </span> <span> . 2021</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_geophysical-geochemical-exploration_thesis/0201290688309.html">基于去低频化的低幅度构造识别方法研究及应用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=夏红敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 夏红敏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郑小文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郑小文</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄捍东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄捍东</a> <span> <a href="/journal-cn-5024/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 物探与化探 </a> </span> <span> . 2021</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_telecom-world_thesis/0201236888984.html">一种调制信号为超低频的幅度调制AGC电路设计</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈茂林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈茂林</a> <span> <a href="/journal-cn-8777/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 通讯世界 </a> </span> <span> . 2018</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-34041_thesis/020221016187.html">低频大气无线电噪声的幅度统计模型研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蒋宇中&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 蒋宇中</a> <span> <a href="/conference-cn-34041/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国海洋学会第二届海洋电磁学研讨会 </a> <span> <span> . 1997</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020311923144.html">放松训练对正常状态和应激状态下心率、T波幅度的影响研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=范全富&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 范全富</a> <span> . 2001</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120652582.html">低频动态电源的输入电流低频波动控制器</a> <b>[P]</b> . <span> 中国专利： CN101345484B </span> <span> . 2010.09.08</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120105549408.html">低频动态电源的输入电流低频波动控制器</a> <b>[P]</b> . <span> 中国专利： CN101345484A </span> <span> . 2009-01-14</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130448192130.html">Process for regulating the pull between the roll stands of roll trains comprises quantitatively acquiring a fluctuation amplitude and fluctuation frequency, and determining a pull and/or the pressure between the roll stands</a> <b>[P]</b> . <span> 外国专利： <!-- 德国专利： --> DE10007364A1 </span> <span> . 2001-03-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于调节轧机机车机架之间的拉力的方法包括定量地获取波动幅度和波动频率，以及确定轧机机架之间的拉力和/或压力。 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130456409632.html">FLUCTUATION CONTROL METHOD AND FLUCTUATION CONTROL EQUIPMENT AS WELL AS LOW FREQUENCY TREATMENT AND LOW FREQUENCY TREATING EQUIPMENT</a> <b>[P]</b> . <span> 外国专利： <!-- 日本专利： --> JPH0947515A </span> <span> . 1997-02-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：波动控制方法和波动控制设备以及低频处理和低频处理设备 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130424307808.html">Method for reducing power supply perturbations of indirect voltage link converter, involves changing pulse frequency when amplitude exceeds predetermined allowable amplitude such that amplitude is set lesser than allowable amplitude</a> <b>[P]</b> . <span> 外国专利： <!-- 德国专利： --> DE102009049820A1 </span> <span> . 2011-04-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：减少间接电压链路转换器的电源扰动的方法，包括当幅度超过预定允许幅度时更改脉冲频率，以使幅度设置为小于允许幅度 </span> </p> 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