Background >Although treatment‐resistant and nontreatment‐resistant depressed pat'/> <meta property="og:document:type" content="pdf"/> <meta property="og:document:page" content="7"/> <meta name="Robots" contect="all"> <meta name="citation_title" content="Amygdala and regional volumes in treatment‐resistant <i >versusversus nontreatment‐resistant depression patients"> <meta name="citation_author" content="Sandu Anca‐Larisa"><meta name="citation_author" content="Artiges Eric"><meta name="citation_author" content="Galinowski André"><meta name="citation_author" content="Gallarda Thierry"><meta name="citation_author" content="Bellivier Frank"><meta name="citation_author" content="Lemaitre Hervé"><meta name="citation_author" content="Granger Bernard"><meta name="citation_author" content="Ringuenet Damien"><meta name="citation_author" content="Tzavara Eleni T."><meta name="citation_author" content="Martinot Jean‐Luc"><meta name="citation_author" content="Paillère Martinot Marie‐Laure"> <meta name="citation_publication_date" content="2017"> <meta name="citation_journal_title" content="Depression and anxiety"> <meta name="citation_volume" content="34"> <meta name="citation_issue" content="11"> <link rel="canonical" href="https://www.zhangqiaokeyan.com/journal-foreign-detail/0704025195436.html"/> <link rel="shortcut icon" href="https://cdn.zhangqiaokeyan.com/favicon.ico"> <link rel="alternate" media="only screen and (max-width: 640px)" href="https://m.zhangqiaokeyan.com/journal-foreign-detail/0704025195436.html"/> <title>Amygdala and regional volumes in treatment‐resistant <i >versusversus nontreatment‐resistant depression patients
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Amygdala and regional volumes in treatment‐resistant versusversus nontreatment‐resistant depression patients

机译：Amygdala和治疗抗性的区域体积与与非抗性抑郁症患者相比

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Background >Although treatment‐resistant and nontreatment‐resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented. </section> <section xml:id="da22675-sec-0020"> <title type="main">Methods >A whole‐brain voxel‐based morphometry (VBM) analysis of regional volumes was performed in 125 participants’ magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment‐resistant depression (TRD), 40 nontreatment‐resistant depression (non‐TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates. </section> <section xml:id="da22675-sec-0030"> <title type="main">Results >TRD patients had higher gray matter (GM) volume in the left and right amygdala than non‐TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non‐TRD bipolar and non‐TRD unipolar patients. An exploratory analysis showed that lithium‐treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres. </section> <section xml:id="da22675-sec-0040"> <title type="main">Conclusions >Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <第XML：ID =“da22675-ec-0010”> <标题类型=“main”>背景</ title> >虽然有处理耐用抗性抑郁患者显示结构脑异常相对于健康对照，这两组之间的区域体积差异仍然没有记录。</ p> </ section> <section xml：id =“da22675-sec-0020”> <标题类型=“main”>方法</标题> >在1.5特斯拉扫描仪上获得的125名参与者的磁共振图像中进行区域体积的全脑体素的形态学（VBM）分析; 41具有治疗抑制（TRD），40个抗性抑制（非TRD），44例是健康的对照。这些群体对年龄和性别相当。作为协变量考虑了双极/单极性的特征和药理治疗类。</ p> </ section> <section xml：id =“da22675-sec-0030”> <标题类型=“main”>结果</标题> > Trd患者在左右杏仁塔的灰质（GM）体积比非TRD患者更高。在TRD双极和TRD单极患者之间或非TRD双极和非TRD单极患者之间没有差异。探索性分析表明，两组锂处理的患者在两个半球中的上额前吉尔里含有更高的GM体积。</ p> </ section> <section XML：ID =“DA22675-SEC-0040”> <标题类型=“main”>结论</标题> >在TRD患者中检测到的Amygdala中的高级血管体积可能是易受慢性的脆弱性的视角，由药物抗性揭示。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2017年第11期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sandu Anca‐Larisa&option=202" target="_blank" rel="nofollow">Sandu Anca‐Larisa;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Artiges Eric&option=202" target="_blank" rel="nofollow">Artiges Eric;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Galinowski André&option=202" target="_blank" rel="nofollow">Galinowski André;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gallarda Thierry&option=202" target="_blank" rel="nofollow">Gallarda Thierry;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bellivier Frank&option=202" target="_blank" rel="nofollow">Bellivier Frank;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lemaitre Hervé&option=202" target="_blank" rel="nofollow">Lemaitre Hervé;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Granger Bernard&option=202" target="_blank" rel="nofollow">Granger Bernard;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ringuenet Damien&option=202" target="_blank" rel="nofollow">Ringuenet Damien;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tzavara Eleni T.&option=202" target="_blank" rel="nofollow">Tzavara Eleni T.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Martinot Jean‐Luc&option=202" target="_blank" rel="nofollow">Martinot Jean‐Luc;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Paillère Martinot Marie‐Laure&option=202" target="_blank" rel="nofollow">Paillère Martinot Marie‐Laure;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Institut National de la Santé et de la Recherche Médicale INSERM Unit 1000 “Neuroimaging &</p> <p>Psychiatry”University Paris Sud–Paris SaclayOrsay France;</p> <p>Institut National de la Santé et de la Recherche Médicale INSERM Unit 1000 “Neuroimaging &</p> <p>Psychiatry”University Paris Sud–Paris SaclayOrsay France;</p> <p>Institut National de la Santé et de la Recherche Médicale INSERM Unit 1000 “Neuroimaging &</p> <p>Psychiatry”University Paris Sud–Paris SaclayOrsay France;</p> <p>SHU Sainte‐Anne HospitalParis France;</p> <p>APHP Department of PsychiatryFernand Widal HospitalParis France;</p> <p>Institut National de la Santé et de la Recherche Médicale INSERM Unit 1000 “Neuroimaging &</p> <p>Psychiatry”University Paris Sud–Paris SaclayOrsay France;</p> <p>APHP Department of PsychiatryTarnier Hospital and University Paris DescartesParis France;</p> <p>Service de Psychiatrie et AddictologieH?pital Paul BrousseAPHP Villejuif France;</p> <p>Institut National de la Santé et de la Recherche Médicale INSERM Unit 1000 “Neuroimaging &</p> <p>Psychiatry”University Paris Sud–Paris SaclayOrsay France;</p> <p>Institut National de la Santé et de la Recherche Médicale INSERM Unit 1000 “Neuroimaging &</p> <p>Psychiatry”University Paris Sud–Paris SaclayOrsay France;</p> <p>Institut National de la Santé et de la Recherche Médicale INSERM Unit 1000 “Neuroimaging &</p> <p>Psychiatry”University Paris Sud–Paris SaclayOrsay France;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biological markers&option=203" rel="nofollow">biological markers;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bipolar disorder&option=203" rel="nofollow">bipolar disorder;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=brain imaging/neuroimaging&option=203" rel="nofollow">brain imaging/neuroimaging;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=depression&option=203" rel="nofollow">depression;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=treatment resistance&option=203" rel="nofollow">treatment resistance;</a> </p> <div class="translation"> 机译：生物标志物;双相障碍;脑成像/神经影像学;抑郁症;治疗抵抗; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蒋松&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,蒋松</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李鑫&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李鑫</a> <span> <a href="/journal-cn-7136/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 养殖技术顾问 </a> </span> <span> . 2018</span><span>,第011期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-anhui-agricultural-sciences_thesis/020121447363.html">接种BmNPV后抗性品种和非抗性品种家蚕组织中2种酶活性的比较研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李龙&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李龙</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张蕾&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张蕾</a> <a 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2009</span><span>,第4期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-67382_thesis/020223036969.html">多西他赛联合雌莫司汀治疗43例抵抗性晚期前列腺癌患者临床疗效观察</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张永利&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张永利</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴坤&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吴坤</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谭琨&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,谭琨</a> <span> <a href="/conference-cn-67382/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第五届中国中医药信息大会 </a> <span> <span> . 2018</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314769415.html">六钩蚴侵染期抗性和非抗性哈萨克羊小肠差异表达miRNA的筛选</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蒋松&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 蒋松</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112604131.html">使用NLRP3拮抗剂治疗对TNF抑制剂有抗性的受试者或针对所述患者选择治疗的方法</a> <b>[P]</b> . <span> 中国专利： CN112654350A </span> <span> . 2021-04-13</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120101781314.html">诊断和治疗具有或发展对于第一种癌症治疗的抗性的患者中的癌症的方法</a> <b>[P]</b> . <span> 中国专利： CN103038364A </span> <span> . 2013-04-10</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130417748454.html">METHODS FOR REDUCING THE EMERGENCY FREQUENCY OF A RESISTANT TREATMENT HEPATITIS C VIRAL INFECTION TO DELAY THE EMERGENCY OF A TREATMENT RESISTANT HEPATITIS C VIRAL INFECTION TO REDUCE THE RESISTANCE LEVEL OF A VIRAL TREATMENT INFECTION TO REDUCE THE EMERGENCY OF AN HCV-796 RESISTANT HEPATITIS C VIRAL INFECTION, TO IDENTIFY AN INDIVIDUAL WITH A REDUCED PROBABILITY TO ANTI-HEPATITIS DIAGNOSTIC OR DIAGNOSTIC DIAGNOSIS MONITORING TREATMENT IN A PATIENT TO MONITOR THE TREATMENT COURSE OF HEPATITIS C VIRAL INFECTION IN A PATIENT TO PROGNOSTIC DEVELOPMENT OF A HEPATITIS C VIRAL INFECTION RESISTANT TO MONITOR THE INFECTION OF A HEPATITIS C PATIENT AND TO DIAGNOSE THE DEVELOPMENT OF A HEPATITIS VIRAL INFECTION OF TREATMENT IN A PATIENT YOU</a> <b>[P]</b> . <span> 外国专利： <!-- --> BRPI0715714A2 </span> <span> . 2014-03-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：减少抗性治疗丙型肝炎病毒感染的出现频率以延缓治疗性抗性丙型肝炎病毒感染的出现频率以减少病毒性感染的耐药水平以降低复发率的方法796 ，以在监测患者抗肝炎病毒感染的治疗过程中对感染的原发性发展进行监测，以监测患者对肝炎的诊断或诊断诊断的可能性，从而监测患者的肝炎病毒感染的治疗过程肝炎患者并诊断您所治疗的肝炎病毒感染的发展 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130409499825.html">method for determining if ec145 is indicated for the treatment of a patient with an ovarian tumor or a lung tumor; method for predicting a response from an ovarian tumor or a lung tumor of a patient to ec145 therapy; method of treating platinum-resistant ovarian cancer in a patient in need; use of ec145 in combination with pegylated liposomal doxorubicin; use of ec145 for the manufacture of a medicament; method for obtaining a clinical benefit compared to treatment with a therapeutic amount of pegylated liposomal doxorubicin in the treatment of platinum-resistant ovarian cancer in a patient in need thereof; method for selecting a patient for treatment; pharmaceutical composition; dosage unit, method for determining if a patient with a tumor has functionally active folate receptors present in the patient's tumor; method of treating a folate receptor expressing epithelial tumor in a patient in need thereof; and; method for obtaining a clinical benefit in the treatment of a folate recepto</a> <b>[P]</b> . <span> 外国专利： <!-- --> BR112012002064A2 </span> <span> . 2017-05-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：确定ec145是否适合治疗卵巢肿瘤或肺肿瘤患者的方法;预测患者的卵巢肿瘤或肺肿瘤对ec145治疗的反应的方法;在有需要的患者中治疗铂耐药的卵巢癌的方法; ec145与聚乙二醇化阿霉素组合使用; ec145在制造药物中的用途;与治疗量的聚乙二醇化脂质体阿霉素治疗相比获得临床益处的方法，在有需要的患者中治疗铂耐药性卵巢癌;选择患者进行治疗的方法;药物组合物;剂量单位，用于确定患有肿瘤的患者是否具有存在于患者肿瘤中的功能活性叶酸受体的方法;在有需要的患者中治疗表达叶酸受体的上皮肿瘤的方法;和;治疗叶酸受体的临床方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130415173629.html">Method for the treatment of refractory depression or resistant taratamiento esketamine which comprises administering intravenous or intranasal alone or in combination with one or more antidepressants; Pharmaceutical Composition and its use in the treatment of Refractory or resistant depression The treatment.</a> <b>[P]</b> . <span> 外国专利： <!-- --> CL2014002406A1 </span> <span> . 2015-01-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于治疗难治性抑郁症或抗药性他他他敏的方法包括：静脉内或鼻内单独或与一种或多种抗抑郁药合用;药物组合物及其在治疗难治性或抵抗性抑郁症中的用途。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025195436','4',7,2,1,'',this,24)" class="delivery" 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