Less is more: Patient‐level meta‐analysis reveals paradoxical dose‐response effects of a computer‐based social anxiety intervention targeting attentional bias

Price Rebecca B.; Kuckertz Jennie M.; Amir Nader; Bar‐Haim Yair; Carlbring Per; Wallace Meredith L.

摘要

Background >The past decade of research has seen considerable interest in computer‐based approaches designed to directly target cognitive mechanisms of anxiety, such as attention bias modification (ABM). </section> <section xml:id="da22634-sec-0020"> <title type="main">Methods >By pooling patient‐level datasets from randomized controlled trials of ABM that utilized a dot‐probe training procedure, we assessed the impact of training "dose" on relevant outcomes among a pooled sample of 693 socially anxious adults. </section> <section xml:id="da22634-sec-0030"> <title type="main">Results > A paradoxical effect of the number of training trials administered was observed for both posttraining social anxiety symptoms and behavioral attentional bias (AB) toward threat (the target mechanism of ABM). Studies administering a large (>1,280) number of training trials showed no benefit of ABM over control conditions, while those administering fewer training trials showed significant benefit for ABM in reducing social anxiety ( P = .02). These moderating effects of dose were not better explained by other examined variables and previously identified moderators, including patient age, training setting (laboratory vs. home), or type of anxiety assessment (clinician vs. self‐report). </section> <section xml:id="da22634-sec-0040"> <title type="main">Conclusions >Findings inform the optimal dosing for future dot‐probe style ABM applications in both research and clinical settings, and suggest several novel avenues for further research. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <第XML：ID =“DA22634-ec-0010”> <标题类型=“main”>背景</ title> >过去十年的研究已经看到了对基于计算机的方法，旨在直接针对焦虑的认知机制的基于计算机的方法，例如注意偏置修改（ABM）。</ p> </ section> <section XML：ID =“DA22634-SEC-0020”> <标题类型=“main”>方法</ title> >通过从ABM的随机对照试验中汇集患者级数据集，利用DOT探测培训程序，评估了培训“剂量”对相关结果的影响汇总样品为693个社会焦虑的成年人。</ p> </ section> <section xml：id =“da22634-sec-0030”> <标题类型=“main”>结果</ title> >矛盾的效果观察到培训试验的培训试验，以便对威胁进行攻击性社交焦虑症状和行为注意力偏见（AB）（ABM的目标机制）。施用大（> 1,280）次训练试验的研究表明，ABM的效益无益于控制条件，而施用较少培训试验的人则对ABM减少社会焦虑（ P </ i> = .02）表现出显着的益处。这些剂量的这种调节效果不是最好的其他检查变量和先前识别的中间剂解释，包括患者年龄，训练环境（实验室与家庭）或焦虑评估类型（临床医生与自我报告）。 </ p> </ section> <section XML：ID =“DA22634-SEC-0040”> <标题类型=“main”>结论</ title> >调查结果通知未来DOT探测器风格ABM的最佳剂量在研究和临床环境中的应用，并提出了几个新颖的进一步研究途径。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2017年第12期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Price Rebecca B.&option=202" target="_blank" rel="nofollow">Price Rebecca B.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kuckertz Jennie M.&option=202" target="_blank" rel="nofollow">Kuckertz Jennie M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Amir Nader&option=202" target="_blank" rel="nofollow">Amir Nader;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bar‐Haim Yair&option=202" target="_blank" rel="nofollow">Bar‐Haim Yair;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carlbring Per&option=202" target="_blank" rel="nofollow">Carlbring Per;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wallace Meredith L.&option=202" target="_blank" rel="nofollow">Wallace Meredith L.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>University of Pittsburgh Pittsburgh PA;</p> <p>San Diego State University San Diego CA;</p> <p>San Diego State University San Diego CA;</p> <p>Tel Aviv University Tel Aviv Israel;</p> <p>Stockholm University Stockholm Sweden;</p> <p>University of Pittsburgh Pittsburgh PA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=attention bias modification&option=203" rel="nofollow">attention bias modification;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=attention training&option=203" rel="nofollow">attention training;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dose‐response&option=203" rel="nofollow">dose‐response;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=patient‐level meta‐analysis&option=203" rel="nofollow">patient‐level meta‐analysis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=social anxiety&option=203" rel="nofollow">social anxiety;</a> </p> <div class="translation"> 机译：注意偏见修改;注意训练;剂量 - 反应;患者级元分析;社会焦虑; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195428.html">Less is more: Patient‐level meta‐analysis reveals paradoxical dose‐response effects of a computer‐based social anxiety intervention targeting attentional bias</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Price Rebecca B.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Price Rebecca B.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kuckertz Jennie M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kuckertz Jennie M.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Amir Nader&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Amir Nader,</a> <a href="/journal-foreign-32884/" target="_blank" rel="nofollow" class="tuijian_authcolor">Depression and anxiety .</a> <span>2017</span><span>,第12期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：更少：患者水平的荟萃分析揭示了针对旨在偏见的计算机的社会焦虑干预的矛盾剂量 - 反应效应</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204121146336.html">Protracted amygdalar response predicts efficacy of a computer-based intervention targeting attentional patterns in transdiagnostic clinical anxiety</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mary L. 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