Explaining the association between anxiety disorders and alcohol use disorder: A twin study

Torvik Fartein Ask; Rosenstr?m Tom Henrik; Gustavson Kristin; Ystrom Eivind; Kendler Kenneth S.; Bramness J?rgen G.; Czajkowski Nikolai; Reichborn‐Kjennerud Ted

摘要

Abstract <section xml:id="da22886-sec-0010" numbered="no"> <title type="main">Background >It is unknown whether social anxiety disorder (SAD) has a unique association with alcohol use disorder (AUD) over and beyond that of other anxiety disorders, how the associations develop over time, and whether the associations are likely to be causal. </section> <section xml:id="da22886-sec-0020" numbered="no"> <title type="main">Methods >Diagnoses of AUD, SAD, generalized anxiety disorder, panic disorder, agoraphobia, and specific phobias were assessed twice using the Composite International Diagnostic Interview among 2,801 adult Norwegian twins. The data were analyzed using logistic regression analyses and multivariate biometric structural equation modeling. </section> <section xml:id="da22886-sec-0030" numbered="no"> <title type="main">Results >SAD had the strongest association with AUD, and SAD predicted AUD over and above the effect of other anxiety disorders. In addition, SAD was prospectively associated with AUD, whereas other anxiety disorders were not. AUD was associated with a slightly elevated risk of later anxiety disorders other than SAD. Biometric modeling favored a model where SAD influenced AUD compared to models where the relationship was reversed or due to correlated risk factors. Positive associations between AUD and other anxiety disorders were fully explained by shared genetic risk factors. </section> <section xml:id="da22886-sec-0040" numbered="no"> <title type="main">Conclusions >Unlike other anxiety disorders, SAD plausibly has a direct effect on AUD. Interventions aimed at prevention or treatment of SAD may have an additional beneficial effect of preventing AUD, whereas interventions aimed at other anxiety disord </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：lang =“en”> <title类型=“main”>抽象</ title> <section XML：ID =“DA22886-SEC-0010”编号=“否”> <标题类型=“main”>背景</ title> >是未知社交焦虑症（悲伤）与其他焦虑症的饮酒障碍（AUD）有独特的关联，联想如何随着时间的推移而发展，以及关联是否可能是因果的。</ p> </ section> <secto xml：id =“da22886-sec-0020”编号=“否”> <标题类型=“main”>方法</ title> >在2,801名成年挪威双胞胎中使用综合国际诊断访谈评估了诊所，悲伤，广泛焦虑症，恐慌症，恐惧症和特定恐惧症两次。使用逻辑回归分析和多变量生物识别结构方程建模分析数据。</ p> </段> <部分XML：ID =“da22886-ec-0030”编号=“否”> <标题类型=“main”>结果</标题> >悲伤与澳元和悲伤的预测澳元完全相同，并超过其他焦虑症的效果。此外，悲伤是与澳元有关的，而其他焦虑症不是。除了悲伤之外，DAD与后期焦虑症的风险略高。生物统计学建模有利于悲伤影响的澳元与关系逆转或由于相关风险因素的模型相比。 AUD和其他焦虑障碍之间的阳性协会通过共享的遗传危险因素得到充分解释。</ p> </ section> <secto xml：id =“da22886-sec-0040”编号=“no”> <title type =“main “>结论</ title> >与其他焦虑症不同，悲伤是对澳元的直接影响。旨在预防或治疗悲伤的干预可能对预防审查的额外有益效果，而针对其他焦虑案的干预措施 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2019年第6期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Torvik Fartein Ask&option=202" target="_blank" rel="nofollow">Torvik Fartein Ask;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rosenstr?m Tom Henrik&option=202" target="_blank" rel="nofollow">Rosenstr?m Tom Henrik;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gustavson Kristin&option=202" target="_blank" rel="nofollow">Gustavson Kristin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ystrom Eivind&option=202" target="_blank" rel="nofollow">Ystrom Eivind;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kendler Kenneth S.&option=202" target="_blank" rel="nofollow">Kendler Kenneth S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bramness J?rgen G.&option=202" target="_blank" rel="nofollow">Bramness J?rgen G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Czajkowski Nikolai&option=202" target="_blank" rel="nofollow">Czajkowski Nikolai;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Reichborn‐Kjennerud Ted&option=202" target="_blank" rel="nofollow">Reichborn‐Kjennerud Ted;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Mental DisordersNorwegian Institute of Public HealthOslo Norway;</p> <p>Department of Mental DisordersNorwegian Institute of Public HealthOslo Norway;</p> <p>Department of Mental DisordersNorwegian Institute of Public HealthOslo Norway;</p> <p>Department of Mental DisordersNorwegian Institute of Public HealthOslo Norway;</p> <p>Department of PsychiatryVirginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth UniversityRichmond Virginia;</p> <p>Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health DisordersBrumunddal Norway;</p> <p>Department of Mental DisordersNorwegian Institute of Public HealthOslo Norway;</p> <p>Department of Mental DisordersNorwegian Institute of Public HealthOslo Norway;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=agoraphobia&option=203" rel="nofollow">agoraphobia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=alcohol use disorder&option=203" rel="nofollow">alcohol use disorder;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anxiety disorders&option=203" rel="nofollow">anxiety disorders;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=social anxiety disorder&option=203" rel="nofollow">social anxiety disorder;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=social phobia&option=203" rel="nofollow">social phobia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=specific phobia&option=203" rel="nofollow">specific phobia;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=twin studies&option=203" rel="nofollow">twin studies;</a> </p> <div class="translation"> 机译：广播恐怖症;酒精使用障碍;焦虑症;社交焦虑症;社交恐惧症;特定恐惧症;双语研究; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195352.html">Explaining the association between anxiety disorders and alcohol use disorder: A twin study</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Torvik 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href="/academic-journal-cn_chinese-journal-nervous-mental-diseases_thesis/0201281325366.html">重性抑郁障碍伴酒精使用障碍患者临床特征及应对方式研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=严保平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 严保平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李薇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李薇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张贤峰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张贤峰</a> <span> <a href="/journal-cn-6259/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国神经精神疾病杂志 </a> </span> <span> . 2020</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-general-practice_thesis/0201271482661.html">精神障碍患者共病酒精使用障碍的现况调查研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=严保平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 严保平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李薇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李薇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张贤峰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张贤峰</a> <span> <a href="/journal-cn-16641/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国全科医学 </a> </span> <span> . 2019</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-21840_thesis/02022472701.html">西藏藏族酒精使用障碍的分子遗传流行病学研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郭万军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 郭万军</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=严成英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,严成英</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=巴桑卓玛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,巴桑卓玛</a> <span> <a href="/conference-cn-21840/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国神经科学学会精神神经专业分会第四届全国学术会议暨中华医学遗传学会第七届全国精神病遗传学术会议 </a> <span> <span> . 2007</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315783564.html">鼻中隔偏曲致嗅觉障碍与嗅球体积变化之间的关联研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵畅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赵畅</a> <span> . 2020</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120102002926.html">包括给予二氢杨梅素的治疗酒精中毒、酒精使用障碍以及酒精滥用的方法</a> <b>[P]</b> . <span> 中国专利： CN103269699A </span> <span> . 2013-08-28</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120109582652.html">用于诊断、评价或量化药物使用、药物滥用和麻醉、核间性眼肌瘫痪、注意缺陷障碍伴多动(ADHD)、慢性损伤性脑病、精神分裂症谱系障碍和酒精消耗的方法和试剂盒</a> <b>[P]</b> . <span> 中国专利： CN107106006A </span> <span> . 2017-08-29</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130427913551.html">Derivatives of 3-fluoro-4 4-2-(3,5-dimethylphenyl-phenyl benzimide; Drug synthesis; Used in the treatment of alcohol disorders, anxiety disorders, depression, schizophrenia, etc.</a> <b>[P]</b> . <span> 外国专利：  CL2009000050A1 </span> <span> . 2010-02-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：3-氟-4 [4- [2-（3,5-二甲基苯基]-苯基]苯甲酰亚胺的衍生物;药物合成;用于治疗酒精障碍，焦虑症，抑郁症，精神分裂症等 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130440126299.html">Compound; method of treatment of an individual with depression, anxiety, panic disorder, post-traumatic tension, premenstrual dysphoric, attention deficit, obsessive-compulsive and eating disorders, obesity, vasomotor flushing, alcohol dependence and cocaine and sexual dysfunction; pharmaceutical composition and use thereof</a> <b>[P]</b> . <span> 外国专利：  BR0314277A </span> <span> . 2005-07-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：复合;治疗患有抑郁症，焦虑症，恐慌症，创伤后紧张情绪，经前烦躁不安，注意力缺陷，强迫症和进食障碍，肥胖症，血管舒缩潮红，酒精依赖和可卡因及性功能障碍的个体的治疗方法;药物组合物及其用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130440126296.html">Compound; method of treatment of an individual with depression, anxiety, panic disorder, post-traumatic tension, premenstrual dysphoric, attention deficit, obsessive-compulsive and eating disorders, obesity, vasomotor flushing, alcohol dependence and cocaine and sexual dysfunction; pharmaceutical composition and use thereof</a> <b>[P]</b> . <span> 外国专利：  BR0314280A </span> <span> . 2005-07-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：复合;治疗患有抑郁症，焦虑症，恐慌症，创伤后紧张情绪，经前烦躁不安，注意力缺陷，强迫症和进食障碍，肥胖症，血管舒缩潮红，酒精依赖和可卡因及性功能障碍的个体的治疗方法;药物组合物及其用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" 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