Functional MRS of GABA 1,GABAand macromolecules in human visual cortex at 3 Tesla

摘要

The glutamate/GABA relation is an important indicator of CNS functioning. MEGA-PRESS pulse sequence is widely used for the measurement of GABA and glutamate + glutamine (Glx) at 3T [1]. However, the presence of the macromolecular (MM) signal in MEGA-PRESS GABA + spectra at 3 ppm may affect the small changes in [GABA] caused by any reason, for example, by mTBI [2] or neuronal activation. The aim of this study is to reveal changes in GABA +,GABA- and pure MM signal intensities in activated visual cortex. This would allow to assess the influence of MM on the accuracy of GABA measurements.