ISMP Adverse Drug Reactions:Minocycline-lnduced Drug Fever Without Skin Rash Lupus Erythematosus-Like Eruption Induced by Hydroxyurea Cardiotoxicity and Fever Induced by Clozapine Denosumab-lnduced Hepatotoxicity Severe Cardiotoxicity Induced by Bevacizumab

摘要

A 24-year-old female had been receiving minocycline 100 mg daily for 6 days for the treatment of acne. The patient reported a fever of 39.2°C (102.6°F), dizziness, chest tightness, and eye pain. Her physician diagnosed her with a cold and she was treated. Minocycline therapy was stopped at this time. The patient's fever and malaise lasted 5 days. Three days later, the patient was restarted on minocycline for her acne. Within 3 hours of minocycline administration, she again developed a high fever of 39.2°C with dizziness, chest tightness, and eye pain.