Elevation of CD16(+)CD56(+) NK-cells and down-regulation of serum interleukin-21 (IL-21) and IL-1 alpha after splenectomy in relapsed hemophagocytic lymphohistiocytosis of unknown cause

摘要

Objectives: Encouraging progress has been made in application of splenectomy in the treatment of relapsed hemophagocytic lymphohistiocytosis (HLH) of unknown cause. The aim was to determine the roles of lymphocyte subpopulations and inflammatory cytokines in splenectomy.