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首页> 外文期刊>Helicobacter >A simple and cost‐efficient adherent culture platform for human gastric primary cells, as an in vitro model for Helicobacter pyloriHelicobacter pylori infection
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A simple and cost‐efficient adherent culture platform for human gastric primary cells, as an in vitro model for Helicobacter pyloriHelicobacter pylori infection

机译：一种用于人胃主细胞的简单且经济高效的粘附培养平台，作为幽门螺杆菌的体外模型幽门螺杆菌感染

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Abstract <section numbered="no" xml:id="hel12489-sec-0001"> <title type="main">Background > Most two‐ dimensional in vitro models for studying host‐ H. pylori interactions rely on tumor‐derived cell lines, which harbor malignant alterations. The recent development of human gastric organoids has overcome this limitation and provides a highly sophisticated, yet costly, short‐term model for H.?pylori infection, with restricted use in low‐budget centers. </section> <section numbered="no" xml:id="hel12489-sec-0002"> <title type="main">Method > Tissue specimens from upper, middle, and lower stomachs of H.?pylori ‐negative volunteers were collectively dispersed and cultured on mouse embryonic fibroblast ( <fc>MEF</fc> ) or collagen‐coated plates. Gastric primary cells ( <fc>GPC</fc> s) were evaluated by light microscopy, immunostaining, <fc>qRT</fc> ‐ <fc>PCR</fc> and <fc>ELISA</fc> analysis of cellular secretions, before and after H.?pylori infection. </section> <section numbered="no" xml:id="hel12489-sec-0003"> <title type="main">Results > The formation and long‐term (up to 1?year) maintenance of <fc>GPC</fc> s was highly dependent on adherent inactivated <fc>MEF</fc> cells, cultured in enriched media. These cells were multipassageable and able to undergo stable freezer storage and subsequent revival. The cellular composition of <fc>GPC</fc> s included the combination of cytokeratin 18 ( <fc </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“Hel12489-Abs-0001”XML：Lang =“en”> <title类型=“main”>抽象</ title> <sectouned =“no”xml：id = “Hel12489-sec-0001”> <标题类型=“main”>背景</标题> >用于学习主机 - h的大多数二维体外模型。 Pylori </ i>相互作用依赖于肿瘤衍生的细胞系，其包围恶性改变。最近的人胃有机体的发展已经克服了这一限制，并为 H.?普罗尼感染提供了高度复杂，但昂贵的短期模型，具有限制性在低预算中心的限制。 </ p> </段> <部分编号=“否”XML：ID =“HEL12489-SEC-0002”> <标题类型=“main”>方法</ title> >中间，中间，中间的组织标本和 H.?丙棒的下胃，志愿者统称并在小鼠胚胎成纤维细胞（<FC> MEF </ Fc>）或胶原涂层的板上培养。通过光学显微镜，免疫染色，<FC> QRT </ Fc> - <Fc> PCR </ Fc>和<Fc> ELISA分析评估胃主细胞（<FC> GPC </ Fc> S）细胞分泌物，在<i之后 H.?普罗尼（H2）感染。 </ p> </ section> <secteneded =“no”xml：id =“hel12489-sec-0003”> <标题类型=“main”>结果</ title> >形成和长期（高达1？一年）<FC> GPC> S的维持高度依赖于富集培养基中培养的粘附失活的<FC> MEF <FC>细胞。这些细胞是多可分散的并且能够进行稳定的冷冻储存和随后的复兴。 <Fc> GPC </ Fc> S的细胞组合物包括细胞角蛋白18的组合（<Fc </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32409/'>《Helicobacter》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Saberi Samaneh&option=202" target="_blank" rel="nofollow">Saberi Samaneh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pournasr Behshad&option=202" target="_blank" rel="nofollow">Pournasr Behshad;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Farzaneh Zahra&option=202" target="_blank" rel="nofollow">Farzaneh Zahra;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Esmaeili Maryam&option=202" target="_blank" rel="nofollow">Esmaeili Maryam;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hosseini Mahmoud Eshagh&option=202" target="_blank" rel="nofollow">Hosseini Mahmoud Eshagh;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Baharvand Hossein&option=202" target="_blank" rel="nofollow">Baharvand Hossein;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mohammadi Marjan&option=202" target="_blank" rel="nofollow">Mohammadi Marjan;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>HPGC Research GroupPasteur Institute of IranTehran Iran;</p> <p>Department of Stem Cells and Developmental BiologyRoyan Institute for Stem Cell Biology and TechnologyTehran Iran;</p> <p>Department of Stem Cells and Developmental BiologyRoyan Institute for Stem Cell Biology and TechnologyTehran Iran;</p> <p>HPGC Research GroupPasteur Institute of IranTehran Iran;</p> <p>Gastroenterology DepartmentTehran University of Medical SciencesTehran Iran;</p> <p>Department of Stem Cells and Developmental BiologyRoyan Institute for Stem Cell Biology and TechnologyTehran Iran;</p> <p>HPGC Research GroupPasteur Institute of IranTehran Iran;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=epithelial&option=203" rel="nofollow">epithelial;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gastric&option=203" rel="nofollow">gastric;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Helicobacter pylori&option=203" rel="nofollow">Helicobacter pylori;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=human&option=203" rel="nofollow">human;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=primary&option=203" rel="nofollow">primary;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=progenitor&option=203" rel="nofollow">progenitor;</a> </p> <div class="translation"> 机译：上皮;胃;幽门螺杆菌;人;小学;祖子; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025099143.html">A simple and cost‐efficient adherent culture platform for human gastric primary cells, as an in vitro model for <i >Helicobacter pyloriHelicobacter pylori infection</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Saberi Samaneh&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Saberi Samaneh,</a> <a 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infection in vitro</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Philipp Schlaermann&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Philipp Schlaermann,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Benjamin Toelle&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Benjamin Toelle,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hilmar Berger&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hilmar Berger,</a> <span>-1</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：原始文章：用于体外模拟幽门螺杆菌感染的新型人胃原代细胞培养系统</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/0100066597125.html ">A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Schlaermann, P.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Schlaermann, P.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Toelle, B.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Toelle, B.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Berger, H.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Berger, H.,</a> <span>2016</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一种用于体外模拟幽门螺杆菌感染的新型人胃原代细胞培养系统</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" 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Morio O.</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rioux-Leclercq N.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Rioux-Leclercq N.</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pagenault M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Pagenault M.</a> <span> <a href="/journal-cn-6057/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界核心医学期刊文摘：胃肠病学分册 </a> </span> <span> . 2005</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-journal-complex-medicine_thesis/0201276456141.html">理气和胃清幽汤治疗幽门螺杆菌感染性胃病临床疗效及对幽门螺杆菌清除率的影响分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=季菊萍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 季菊萍</a> <span> <a href="/journal-cn-38764/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界复合医学 </a> </span> <span> . 2019</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-journal-complex-medicine_thesis/0201277083458.html">理气和胃清幽汤治疗幽门螺杆菌感染性胃病临床疗效及对幽门螺杆菌清除率的影响分析</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=季菊萍1&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 季菊萍1</a> <span> <a href="/journal-cn-54375/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界复合医学 </a> </span> <span> . 2019</span><span>,第009期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_hebei-journal-traditional-chinese-medicine_thesis/0201216323679.html">消菌汤治疗幽门螺杆菌感染性胃临床疗效及对幽门螺杆菌清除率的影响</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张惠玲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张惠玲</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨玉杰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨玉杰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵金媛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵金媛</a> <span> <a href="/journal-cn-5654/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 河北中医 </a> </span> <span> . 2016</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-digestion-medical-imageology-electronic-edition_thesis/0201232582414.html">上调自噬对幽门螺杆菌感染后人胃上皮细胞 GES-1的保护作用</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=熊励晶&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 熊励晶</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=童煜&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,童煜</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=谢晓丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,谢晓丽</a> <span> <a href="/journal-cn-6032/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中华消化病与影像杂志（电子版） </a> </span> <span> . 2015</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-23025_thesis/02022775214.html">护胃中成药对幽门螺杆菌增殖及粘附胃上皮细胞的研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=宋于刚&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 宋于刚</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姚永莉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,姚永莉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张万岱&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张万岱</a> <span> <a href="/conference-cn-23025/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国中西医结合学会第十八次全国消化系统疾病学术会议 </a> <span> <span> . 2006</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020316372920.html">幽门螺杆菌感染新型原代人胃上皮细胞模型的建立和应用</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=高爽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 高爽</a> <span> . 2021</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120203215514.html">一种光谱式胃中幽门螺杆菌感染诊断装置</a> <b>[P]</b> . <span> 中国专利： CN203216844U </span> <span> . 2013.09.25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120108349389.html">一种用于诊断人体幽门螺杆菌感染试剂盒以及检测人体呼气中氨气含量的方法</a> <b>[P]</b> . <span> 中国专利： CN105866224A </span> <span> . 2016-08-17</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130449100227.html">Compound, process for the preparation of it, pharmaceutical formulation, use of the compound, processes to inhibit gastric acid secretion, for the treatment of inflammatory gastrointestinal diseases, and for the treatment or prophylaxis of conditions involving helicobacter pylori infection of the mucosa human gastric, and, pharmaceutical formulations for use in inhibiting gastric acid secretion, for use in the treatment of inflammatory gastrointestinal diseases, and for use in the treatment or prophylaxis of conditions involving helicobacter pylori infection of the human gastric mucosa</a> <b>[P]</b> . <span> 外国专利： <!-- --> BR9913103A </span> <span> . 2001-05-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：该化合物，其制备方法，药物制剂，该化合物的使用，抑制胃酸分泌的方法，用于治疗炎性胃肠疾病以及用于治疗或预防人胃黏膜幽门螺杆菌感染的疾病的方法，以及用于抑制胃酸分泌，用于治疗炎性胃肠疾病以及用于治疗或预防涉及人胃粘膜的幽门螺杆菌感染的疾病的药物制剂 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130450891686.html">Vaccine composition, use of a helicobacter pylori polypeptide flge or a modified form thereof, use of the same, vaccine composition to induce a protective immune response to helicobacter pylori infection, in vitro diagnostic process of helicobacter pylori infection, kit method for detecting helicobacter pylori infection in a mammal including man, and process for eliciting a protective immune response against helicobacter pylori infection in a mammal</a> <b>[P]</b> . <span> 外国专利： <!-- --> BR9810026A </span> <span> . 2000-09-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：疫苗组合物，幽门螺杆菌多肽壁或其修饰形式的用途，其用途，疫苗组合物诱导对幽门螺杆菌感染的保护性免疫应答，幽门螺杆菌感染的体外诊断方法，用于检测幽门螺杆菌感染的试剂盒方法包括人在内的哺乳动物中的表达，以及引起针对幽门螺杆菌感染的保护性免疫应答的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130425480225.html">composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion</a> <b>[P]</b> . <span> 外国专利： <!-- --> BRPI0617987A2 </span> <span> . 2011-08-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img 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