A Perioperative Small Dose of Dexamethasone Enhances Postoperative Recovery by Reducing Volume and Inflammatory Contents in Wound Drainage After Thyroid Surgery: A Double-Blinded, Randomized, Prospective Study

摘要

BackgroundThe aims of this study were to assess the effect of perioperative dexamethasone on postoperative thyroid surgery recovery using measures of wound drainage volume and C-reactive protein (CRP) levels and leukocyte counts.Materials and methodsFrom January to September 2014, healthy patients, aged between 18 and 65years, had elective thyroid surgery in the tertiary hospital. Eligible patients were randomized into either group D (dexamethasone 0.1mg/kg IV) or group S (saline IV) after anesthesia induction. At the end of surgery, a drainage tube was placed at the thyroid bed with a negative pressure ball connected outside the wound. Drainage fluids were collected after thyroid surgery. The fluid volume and the levels of C-reactive protein and leukocyte counts inside were analyzed. All patients were followed up for 1month.ResultsThe median total drainage in group D (n=103) was 43ml (IQR: 21-83ml), and 68ml (IQR: 35-104ml) in group S (n=111), P=0.002. More patients in group D were discharged on postoperative day 2 (74.8% vs. 54.1%, P=0.002). The CRP levels and leukocyte counts were much less in group D than in group S (P=0.002 and P<0.001, respectively). Two patients (one in each group) had wound infections 1week after surgery that healed one additional week later.ConclusionsOne perioperative small dose of dexamethasone reduced wound drainage volume and inflammatory content after thyroid surgery, thereby possibly contributing to early recovery. The effects of dexamethasone have never been evaluated before under these conditions.Registration number:NCT02304250 (http://www.clinicaltrials.gov).