Organoboranes for Asymmetric Synthesis

摘要

Since its introduction 20 years ago,DIP-Chloride~(TM) (B-chlorodiisopino-campheylborane,lpc_2BCI,DIP-CI) has become one of the most effective reagents for the asymmetric reduction of prochiral ketones,especially aralkyl and alpha-hindered ketones.The reagent has found popular use in the asymmetric synthesis of ligands,3-amino alcohols,and alkaloids,and is also capable of effecting asymmetric aldol reactions.Furthermore,asymmetric allylations can be achieved when DIP-CI is reacted with allylmagnesium bromide,allowing for further elaboration of the reduced product.We are now offering this valuable reagent also as an easier-to-handle solution in three different solvents: heptane,hexane,and alpha-pinene.