Red cell alloimmunization in transfusion-dependent and transfusion-independent beta thalassemia: A review from the Eastern Mediterranean Region (EMRO)

摘要

Background: beta-Thalassemia is considered one of the common hemoglobin disorders in the Arabian Peninsula. Red blood cell (RBC) transfusion is a crucial component of the management of transfusion-dependent beta-Thalassemia patients. Patients with Thalassemia Intermedia (TI), also known as non-transfusion dependent beta-thalassemia, have a wide clinical presentation and variable transfusion dependence. Rates of RBC alloimmunization and its risk factors in transfusion-dependent beta-thalassemia patients varied between different reports. Risk of alloimmunization is higher in TI patients.